PMID: 702060Oct 1, 1978Paper

Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides

The Journal of Experimental Medicine
G P HaasA Nowotny

Abstract

The experiments described herein demonstrate the plaque-forming cell response of C3H/HeJ mice can be suppressed by a Boivin type lipopolysaccharide (LPS) and a deproteinized glycolipid. Suppression was observed both in vivo and in vitro, and could be transferred to normal cells in coculture experiments. This newly discovered effect of LPS in C3H/HeJ mice indicates that the adjuvant and inhibitory action of LPS may be distinct phenomena which are under different genetic regulation. Thus, the C3H/HeJ strain provides a convenient animal model for study of immunosuppression independent of the adjuvant effect.

References

Sep 1, 1976·The Journal of Experimental Medicine·D C MorrisonD M Jacobs
Sep 1, 1976·The Journal of Experimental Medicine·B M Sultzer, G W Goodman
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton

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Citations

Jul 1, 1991·Journal of Neuroimmunology·J B BaxterD A Weigent
Jan 1, 1985·Critical Reviews in Microbiology·F Quimby, H T Nguyen
Nov 1, 1988·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·G Gillissen
Jan 1, 1982·Annals of the New York Academy of Sciences·Y M KongL Chedid
Mar 15, 1981·Cellular Immunology·L P RucoC D Baroni
Oct 1, 1979·Infection and Immunity·F W ChorpenningJ W Oldfather
Sep 1, 1980·Infection and Immunity·S V GollapudiM Kern
Mar 1, 1982·Cellular Immunology·R A WinchurchA Munster

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