Suppression of the immune response to altered self induced by immunogenic and nonimmunogenic altered self structures

European Journal of Immunology
T RamosG Möller

Abstract

Fluorescein (FITC)-haptenated mouse spleen cells are capable of inducing a B cell immune response characterized by the production of antibodies directed against hapten-altered self structures. The induction of this response is thymus-independent and strictly dependent on the hapten concentration used for labeling the cells. Pretreatment of mice with immunogenic, labeled spleen cells strongly suppressed the plaque-forming cell response to a subsequent challenge with FITC-labeled spleen cells, sheep (SRC) or horse (HRC) red cells labeled with the same hapten and native FITC-dextran. Mice primed with lightly haptenated (nonimmunogenic) cells 7 days before challenge were completely unresponsive to the immunogenic dose of labeled cells and displayed a significantly reduced response to FITC-SRC or FITC-HRC. However, the response to FITC-dextran was enhanced, as compared to unprimed animals. The concept of immunogenic vs. nonimmunogenic requirements of an antigen to induce unresponsiveness, and the specificity of the B cell clones affected by suppression is discussed.

References

Sep 1, 1972·The Journal of Experimental Medicine·C S WaltersH N Claman
Dec 1, 1972·European Journal of Immunology·W W Bullock, E Möller
Apr 1, 1974·The Journal of Experimental Medicine·G Möller
Apr 1, 1974·European Journal of Immunology·J A Hamilton, J F Miller
Jan 1, 1968·Advances in Immunology·J W UHR, G Möller
Jul 11, 1970·Nature·G E Roelants, J W Goodman
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Jun 1, 1965·The Journal of Experimental Medicine·G Möller, H Wigzell
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Citations

Dec 1, 1987·Cellular Immunology·M Zöller, G Andrighetto
Jul 1, 1985·Scandinavian Journal of Immunology·M ZöllerG Andrighetto
Oct 1, 1984·Scandinavian Journal of Immunology·M ZöllerG Andrighetto
Sep 1, 1987·Scandinavian Journal of Immunology·M Zöller, G Andrighetto
Jan 1, 1982·Annals of the New York Academy of Sciences·G MöllerT Ramos
Sep 1, 1987·European Journal of Immunology·I Z QuintanaG Möller

Related Concepts

Antibody Formation
Antigens
B-Lymphocytes
Tetraiodofluorescein
Cavia porcellus
Haptens
Hemolytic Plaque Technique
Natural Immunosuppression
Variolation
Therapeutic Immunosuppression

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