Abstract
Colorectal cancer (CRC) is a major cause of mortality and morbidity. Chronic inflammation is closely associated with the development, progression and prognosis of the majority of intestinal malignancies. In recent years, targeting the nuclear factor (NF)‑κB signaling pathway for CRC therapy has become an attractive strategy. Riccardin D, a novel macrocyclicbis (bibenzyl) compound, was isolated from the Chinese liverwort plant. Previous studies have suggested that Riccardin D exerted chemo‑preventative effects against the intestinal malignancy formation. In the present study, cell counting kit‑8, Hochest 33258 staining, mitochondria membrane permeability assay, western blotting analysis, reverse transcription‑polymerase chain reaction, luciferase reporter gene assay and molecular modeling analysis were performed to detect the effect and mechanisms of Riccardin D on human colon cancer cells. The results demonstrated that Riccardin D significantly inhibited the growth of HT‑29 cells. In addition, the cDNA expression of cyclooxygenase‑2, and the protein expression and activity of NF‑κB and tumor necrosis factor‑α were downregulated; however, the protein expression of cleaved caspase‑3 and ‑9, and cleaved poly (adenosine diphosphate...Continue Reading
References
Aug 9, 1991·Science·I NishishoP Hedge
Dec 29, 1995·The Journal of Biological Chemistry·K YamamotoS Yamamoto
Mar 21, 1997·Science·P J MorinK W Kinzler
Mar 19, 1999·Molecular and Cellular Biology·M HinzM Strauss
Feb 13, 2001·The Journal of Clinical Investigation·Y Yamamoto, R B Gaynor
Jul 20, 2002·The Journal of Biological Chemistry·Pierre Olivier EstèveYves St-Pierre
Dec 10, 2003·Oncogene·Jérôme KucharczakCéline Gélinas
Jan 2, 2004·Journal of Computer-aided Molecular Design·Robin J RosenfeldArthur J Olson
Feb 16, 2005·The Journal of Biological Chemistry·Yasunari TakadaBharat B Aggarwal
Jun 7, 2006·Journal of Asian Natural Products Research·Zhi-Qiang LuHong-Xiang Lou
Feb 13, 2007·Molecular Cancer Research : MCR·Wade S SamowitzHans Albertsen
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kei SakamotoMasao Omata
May 28, 2009·Archives of Pharmacal Research·Sun Mi KimJin Tae Hong
Jul 15, 2009·Cell Cycle·Reid A PhelpsDavid A Jones
Nov 6, 2009·Cellular & Molecular Immunology·Soly WangXiaoren Zhang
May 21, 2010·Cancer Research·Adelaide M CarothersMonica M Bertagnolli
Jul 14, 2010·Nature Cell Biology·Hsiangling TeoVinay Tergaonkar
Oct 19, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E Angela MurphyMartin D Carmichael
Nov 6, 2010·Gut·Anna E CoghillCornelia M Ulrich
Jan 21, 2011·Current Cancer Drug Targets·Lidija Klampfer
Feb 15, 2011·Methods in Molecular Biology·Delira Robbins, Yunfeng Zhao
Aug 23, 2011·PloS One·María Jesús LarribaHéctor G Pálmer
Nov 8, 2011·Cytokine·Jamie L McClellanE Angela Murphy
Mar 21, 2012·PloS One·Hui-Ping LiuXian-Jun Qu
May 3, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Aristeidis G VaiopoulosAthanasios G Papavassiliou
Aug 27, 2013·International Journal of Molecular Sciences·Sally TemrazAli Shamseddine
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
May 20, 2014·Basic & Clinical Pharmacology & Toxicology·Cui-Cui SunXian-Jun Qu
Jun 20, 2014·World Journal of Gastroenterology : WJG·Gemma BinefaManuel Medina-Hayas
Aug 12, 2014·World Journal of Gastroenterology : WJG·Francesco MarianiLuca Roncucci
Mar 15, 2015·Cell Death & Disease·M ElbazY Nevo
May 21, 2015·World Journal of Experimental Medicine·Miguel Angel Chiurillo
Nov 11, 2015·Molecular Cancer·Yuchen WuYe Xu