Suppression of the nuclear transporter-KPNβ1 expression inhibits tumor proliferation in hepatocellular carcinoma

Medical Oncology
Linlin YangJibin Liu

Abstract

Hepatocellular carcinoma (HCC) is one of the malignant tumors and leads to the highly death in the solid tumors, but its mechanism remains unclear. KPNβ1 is one of the soluble nuclear transport receptors, has been reported to act as an important role in the occurrence and development of tumor, such as cervical cancer, head and neck and lung cancer. However, the expression mechanisms and physiological significance of KPNβ1 in HCC is still unclear. The expression of KPNβ1 and its involvement in HCC was studied. The expression of KPNβ1 protein was measured by Western blot and immunohistochemistry in HCC. We analyzed the effects of growth and interference of KPNβ1 in the cell cycle process by CCK8 and flow cytometrical analysis. KPNβ1 protein level was up-regulated in HCC tissue samples. The KPNβ1 expression was significantly associated with histological differentiation. The levels of KPNβ1 were significantly correlated with histological grade (P = 0.03), metastasis (P = 0.01), vein invasion (P = 0.04) and tumor size (P = 0.01) in HCC samples. Serum starvation assay proved that KPNβ1 was arrested in G1 phase and was gradually reduced by refeeding serum. Moreover, the knockdown of KPNβ1 induced cell proliferation arrest in HepG2 cel...Continue Reading

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Citations

Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Michiko KodamaNancy A Jenkins
Sep 23, 2020·Investigational New Drugs·Chie IshikawaNaoki Mori
Feb 8, 2018·Current Opinion in Cell Biology·Tolga Çağatay, Yuh Min Chook
Jul 22, 2021·Current Oncology·Chawalit NgernsombatTavan Janvilisri

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