Abstract
Diabetes represents a major public health problem and an estimated 70% of people with diabetes die of cardiovascular complications. The protective effect of insulin treatment against ultrastructural damage to the tunica intima and tunica media of the aorta induced by type 2 diabetes mellitus (T2DM) has not been investigated before using transmission electron microscopy (TEM). Therefore, we induced T2DM in rats using high fat diet and streptozotocin (50 mg/kg) and administered insulin daily by i.v injection for 8 weeks to the treatment group. Whereas, the T2DM control group were left untreated for the duration of the experiment. A comparison was also made between the effect of insulin on aortic tissue and the blood level of biomarkers of vascular injury, inflammation, and oxidative stress. T2DM induced profound ultrastructural damage to the aortic endothelium and vascular smooth muscle cells, which were substantially protected with insulin. Furthermore, insulin returned blood sugar to a control level and significantly (p < .05) inhibited diabetic up-regulation of endothelial and leukocyte intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion protein 1 (VCAM-1), endothelial cell adhesion molecules, P-selectin and E-s...Continue Reading
References
Aug 23, 2000·The Journal of Clinical Investigation·H N Ginsberg
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
May 24, 2008·The Journal of Clinical Investigation·Adama KamagateH Henry Dong
Jun 3, 2009·Current Vascular Pharmacology·Mohamed A HaidaraEsma R Isenovic
Jan 28, 2010·Diabetes Care·Markku Laakso
Dec 8, 2010·Metabolism: Clinical and Experimental·Ebenezer A NyenweAbbas E Kitabchi
Feb 18, 2011·The Journal of Rheumatology·Noriko YoshimuraToru Akune
Jun 28, 2011·Lancet·Goodarz DanaeiUNKNOWN Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Blood Glucose)
Nov 9, 2011·Nature Medicine·Nan Zhang, Daniel A Lawrence
Jan 13, 2012·The American Journal of Pathology·Junyan ShiAleksander Hinek
Feb 3, 2012·Nature·Robert H LustigClaire D Brindis
Mar 12, 2013·Diabetes Care·Evrim B TurkbeyUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
Nov 22, 2013·PloS One·Yong PanGuang Liang
May 24, 2014·Diabetes Care·Philip HomeItamar Raz
Dec 20, 2014·Pediatric Diabetes·Michael A McCullochSamuel S Gidding
Dec 2, 2015·Experimental and Therapeutic Medicine·Wei MuQichong Xing
Mar 5, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·J S PankowS J Bielinski
May 28, 2017·Atherosclerosis·Mette K HagensenJacob F Bentzon
Jul 28, 2018·Cardiovascular Research·Juliette RaffortZiad Mallat
Sep 20, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Y JiaS-W Leung
Nov 23, 2018·Archives of Physiology and Biochemistry·Mohammad A DallakMohamed A Haidara
Jun 30, 2019·Archives of Physiology and Biochemistry·Ismaeel Bin-JaliahBahjat Al-Ani