Abstract
In view of the potentially important role of automaticity in the genesis of ventricular dysrhythmias, the effects of four widely used antidysrhythmic agents on ventricular automaticity were examined in anesthetized dogs at doses previously shown to antagonize experiments induced rhythm disturbances. Quinidine, and particularly procainamide, lidocaine and propranolol slowed ventricular rate in A-V blocked dogs. Quinidine and procainamide but particularly the last two agents also markedly prolonged overdrive suppression. Thus, all four substances depressed automaticity. However, propranolol was effective at doses substantially lower than those required to antagonize several experimental dysrhythmias.
References
Nov 1, 1972·British Journal of Pharmacology·G KelliherJ Roberts
Jan 1, 1971·Annual Review of Pharmacology·A L Bassett, B F Hoffman
Sep 1, 1974·Circulation Research·B J ScherlagR Lazzara
Aug 1, 1973·Circulation·M B PliamC M Brooks
Feb 1, 1974·American Heart Journal·B G GoelR Rogers
Jun 1, 1972·Circulation Research·B J Koerpel, L D Davis
Sep 1, 1972·Circulation·M R RosenB F Hoffman
Mar 1, 1971·Les cahiers du nursing·R Bouliane
Jan 1, 1970·The Journal of Clinical Investigation·J T Bigger, W J Mandel
Sep 1, 1970·Circulation Research·M Vassalle
Sep 1, 1968·The American Journal of Cardiology·N A LiebermanV J Fisher
May 1, 1969·Circulation Research·L D Davis, J V Temte
Jun 25, 1966·Nature·E Nye, J Roberts
Dec 1, 1967·The American Journal of Cardiology·R H HelfantA N Damato
Citations
Oct 1, 1976·European Journal of Pharmacology·T BaumD R Much
Apr 1, 1983·Journal of Pharmacological Methods·C DubrayP Duchene-Marullaz
Jan 1, 1989·General Pharmacology·M ManoachM Erez
Sep 1, 1986·British Journal of Pharmacology·M BoucherJ L Moundanga