Suppression of visually and memory-guided saccades induced by electrical stimulation of the monkey frontal eye field. II. Suppression of bilateral saccades

Journal of Neurophysiology
Yoshiko IzawaYoshikazu Shinoda

Abstract

To understand the neural mechanism of fixation, we investigated effects of electrical stimulation of the frontal eye field (FEF) and its vicinity on visually guided (Vsacs) and memory-guided saccades (Msacs) in trained monkeys and found that there were two types of suppression induced by the electrical stimulation: suppression of ipsilateral saccades and suppression of bilateral saccades. In this report, we characterized the properties of the suppression of bilateral Vsacs and Msacs. Stimulation of the bilateral suppression sites suppressed the initiation of both Vsacs and Msacs in all directions during and approximately 50 ms after stimulation but did not affect the vector of these saccades. The suppression was stronger for ipsiversive larger saccades and contraversive smaller saccades, and saccades with initial eye positions shifted more in the saccadic direction. The most effective stimulation timing for the suppression of ipsilateral and contralateral Vsacs was approximately 40-50 ms before saccade onset, indicating that the suppression occurred most likely in the superior colliculus and/or the paramedian pontine reticular formation. Suppression sites of bilateral saccades were located in the prearcuate gyrus facing the inf...Continue Reading

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Citations

May 6, 2011·Experimental Brain Research·Annelies GeritsWim Vanduffel
Jul 30, 2010·Journal of Cognitive Neuroscience·Masayuki Watanabe, Douglas P Munoz
Oct 2, 2007·Neuroscience Research·Mariko Kuwajima, Toshiyuki Sawaguchi
Apr 14, 2005·Annals of the New York Academy of Sciences·Yuriko SugiuchiYoshikazku Shinoda
Apr 14, 2005·Annals of the New York Academy of Sciences·Yoshiko IzawaYoshikazu Shinoda
Dec 13, 2006·The European Journal of Neuroscience·Thomas NyffelerRené M Müri
Sep 29, 2011·Annals of the New York Academy of Sciences·Yoshikazu ShinodaYoshiko Izawa
Aug 11, 2016·PLoS Biology·Tyler R PeelBrian D Corneil
Aug 23, 2008·Progress in Brain Research·Yoshikazu ShinodaMayu Takahashi
Jan 24, 2007·Nature Neuroscience·Masaki Isoda, Okihide Hikosaka
Mar 8, 2018·Journal of Neurophysiology·Yoshiko Izawa, Hisao Suzuki
Oct 25, 2013·Journal of Neurophysiology·Tyler R PeelBrian D Corneil
Jul 31, 2020·Journal of Neurophysiology·Yoshiko Izawa, Hisao Suzuki
Apr 25, 2014·Journal of Neurophysiology·Yoshiko Izawa, Hisao Suzuki
Aug 14, 2009·Journal of Neurophysiology·Yoshiko IzawaYoshikazu Shinoda

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