Abstract
This study investigated the possibility that Candida albicans components exert a suppressive effect on the immune response of guinea pigs (GP), similar to that of live C. albicans organisms as was previously shown. Hartley GP were inoculated with C. albicans crude cytoplasmic or metabolite (culture filtrate) extracts (containing most of the organism's cell contents or its metabolite and degradation products, respectively). Their immunological responses towards sheep red blood cells (SRBC) were compared with those of GP inoculated with SRBC alone or with SRBC together with live C. albicans organisms. The immunological responses were measured by: 1) rosette formation (RF) of SRBC with peritoneal macrophages, 2) haemolytic plaque formation (PFC) with lymph node-cells, 3) haemagglutination and 4) haemolysis tests. According to the RF tests, inoculation of GP with either cytoplasmic or metabolite extracts resulted in decreased RF as compared to GP inoculated with SRBC only; the decrease was correlated with the protein concentration of the extracts. Inoculation with metabolite extract led to a more diminished RF than with cytoplasmic extract, but less than with live C. albicans organisms. Inoculation of cytoplasmic extracts did not a...Continue Reading
References
Jul 1, 1978·Clinical Immunology and Immunopathology·T J Rogers, E Balish
Apr 1, 1978·Infection and Immunity·T J Rogers, E Balish
Nov 1, 1978·The Journal of Clinical Investigation·A FischerC Griscelli
Jan 1, 1979·Experimental Cell Biology·N Vardinon, E Segal
Aug 1, 1976·Infection and Immunity·A H Good, K L Miller
Mar 1, 1977·Annals of Tropical Medicine and Parasitology·H A Wilkins, J Brown
Sep 1, 1977·European Journal of Immunology·J P DessaintA Capron
Dec 1, 1976·Experimental Parasitology·C A Crandall, R B Crandall
Nov 1, 1976·Cellular Immunology·J F JonesR B Crandall
Apr 1, 1975·Acta Allergologica·E SegalE Eylan
Jul 1, 1975·Acta Allergologica·N VardinonE Eylan
Nov 1, 1971·The Journal of Experimental Medicine·A H Malakian, J H Schwab
Aug 1, 1971·Experimental Parasitology·G Faubert, C E Tanner
Jan 1, 1971·The Journal of Infectious Diseases·L R Barker
Apr 26, 1963·Science·N K Jerne, A A Nordin
Citations
Feb 15, 1984·Mycopathologia·M ZoualiA Eyquem
Oct 30, 1984·Mycopathologia·J C ValdezA Sirena
Jan 1, 1989·International Journal of Immunopharmacology·V VuddhakulY H Thong
Apr 1, 1987·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·M P KolotilaC W Smith
Jan 1, 1992·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·R A Greenfield
Jul 1, 1985·Infection and Immunity·E W Carrow, J E Domer