Abstract
Orexins are hypothalamic neuropeptides which stimulate luteinizing hormone (LH) secretion in estrogen- and progesterone-treated ovariectomized (OVX) rats and suppress it in OVX rats not treated with estrogen, suggesting a modulation by estrogen of the response to orexins. We examined the effects of orexin A on pulsatile LH secretion in OVX rats treated with a very small dose of estrogen so as to maintain the pulsatile secretion of LH. The estrogen treatment was done 24 h before the blood sampling by subcutaneously implanting a silicone tube (id = 1.5 mm, od = 2.5 mm, length = 25 mm) containing 17beta-estradiol (E(2)) dissolved in sesame oil at 20 microg/ml. In OVX rats treated with sesame oil as a control, the intracerebroventricular (icv) injection of orexin A (0.3 nmol, dissolved in 3 microl artificial cerebrospinal fluid) had no significant effect on the parameters of pulsatile LH secretion, i.e., pulse frequency and pulse amplitude, although it caused a small but statistically significant decrease in overall mean LH concentrations within 1 h. In OVX rats treated with E(2), the icv injection of orexin A significantly suppressed the pulsatile LH secretion; the frequency decreased for more than 2 h, inducing a rapid decline in...Continue Reading
Citations
Nov 5, 2003·Frontiers in Neuroendocrinology·Alastair V Ferguson, Willis K Samson
Oct 3, 2009·Acta Physiologica·P SilveyraC Libertun
Dec 29, 2006·Neuroendocrinology·Ravid SassonPamela L Mellon
Jun 8, 2012·Endocrinology·Garrett T Gaskins, Suzanne M Moenter
Dec 2, 2011·PloS One·Kazumi NaritaMichio Takahashi
Dec 18, 2013·Regulatory Peptides·N I CataldiC Libertun
Jan 1, 2012·ISRN Veterinary Science·R M Garcia-Garcia
Jun 17, 2014·Neuropeptides·L MartynskaW Bik
Aug 7, 2010·Regulatory Peptides·Anna NitkiewiczTadeusz Kaminski
Oct 28, 2009·Neuroscience Letters·Nobuhiko SawaiHitoshi Ozawa
Aug 6, 2009·Frontiers in Neuroendocrinology·Miguel LópezCarlos Diéguez
Aug 25, 2009·Regulatory Peptides·Patricia SilveyraCarlos Libertun
Jul 15, 2009·Sleep Medicine·Bijal Kirit MehtaDaniel Rifkin
Apr 28, 2009·Animal Reproduction Science·Tadeusz KaminskiJadwiga Przala
Feb 8, 2008·Research in Veterinary Science·Juan SuJihui Ping
Nov 19, 2003·Biochemical and Biophysical Research Communications·Hong QuanFukuko Kimura
Oct 10, 2013·British Journal of Pharmacology·Jingcheng LiLuis de Lecea
Sep 24, 2004·Neuroscience Letters·Hong QuanFukuko Kimura
Oct 27, 2004·Peptides·Rodrigo A EspañaStephen C Gammie
May 26, 2004·Physiology & Behavior·Jill E Schneider
Jun 24, 2004·Toxicology·Natsumi KatoMasao Hirose
Jan 21, 2015·Reproduction in Domestic Animals = Zuchthygiene·M LevantiF Abbate
Aug 6, 2013·Hormones and Behavior·Jill E SchneiderErin Keen-Rhinehart
Feb 27, 2014·Hormones and Behavior·Iain J Clarke
Sep 16, 2018·Neuromolecular Medicine·Abdolkarim Hosseini, Homayoun Khazali
Nov 24, 2006·American Journal of Physiology. Endocrinology and Metabolism·Patricia SilveyraCarlos Libertun
Jul 20, 2007·American Journal of Physiology. Endocrinology and Metabolism·Patricia SilveyraCarlos Libertun
Mar 18, 2003·Endocrinology·Olaf JöhrenPeter Dominiak