Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis

American Journal of Obstetrics and Gynecology
Jack D SobelSharon L Hillier

Abstract

Efficacy study of suppressive vaginal metronidazole in reducing recurrent symptomatic episodes of bacterial vaginosis. Multicenter prospective study with initial 10-day open-label metronidazole gel in which asymptomatic responders randomly assigned to receive twice weekly metronidazole vaginal gel or placebo for 16 weeks and off therapy for 12 weeks. Of 157 eligible women with recurrent bacterial vaginosis, 112 of 127 returning evaluable women (88.2%) responded clinically and were randomly assigned. During suppressive therapy, recurrent bacterial vaginosis occurred in 13 women (25.5%) receiving metronidazole and 26 (59.1%) receiving placebo (MITT analysis, relative risk [RR] 0.43, CI = 0.25-0.73, P = .001). During the entire 28-week follow-up, recurrence occurred in 26 (51.0%) on treatment compared with 33 (75%) on placebo (RR 0.68, CI = 0.49-0.93, P = .02). Probability for remaining cured was 70% for metronidazole compared with 39% on placebo, which declined to 34% and 18%, respectively, by 28 weeks follow-up. Adverse effects were uncommon; however, secondary vaginal candidiasis occurred significantly more often in metronidazole-treated women (P = .02). Suppressive therapy with twice-weekly metronidazole gel achieves a signifi...Continue Reading

References

Sep 1, 1988·British Journal of Obstetrics and Gynaecology·M VejtorpS S Schrøder
Oct 13, 1988·The New England Journal of Medicine·S L HillierD A Eschenbach
Aug 1, 1993·American Journal of Obstetrics and Gynecology·D A Eschenbach
Aug 1, 1996·American Journal of Obstetrics and Gynecology·S L HillierK K Holmes
Feb 24, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M R JoesoefS L Hillier
Nov 30, 2000·Current Infectious Disease Reports·P Hay
Sep 11, 2002·Obstetrics and Gynecology·Harold C WiesenfeldRichard L Sweet
Sep 28, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly A Workowski, Stuart M Berman
Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Harold C WiesenfeldRichard L Sweet
Jul 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas L CherpesSharon L Hillier
Feb 3, 2004·Sexually Transmitted Infections·J Wilson
Feb 3, 2004·Sexually Transmitted Infections·S SmartA Mindel

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Citations

Sep 9, 2010·Maternal and Child Health Journal·Emilia H KoumansLauri E Markowitz
Oct 28, 2009·Current Infectious Disease Reports·Jack D Sobel
Feb 4, 2012·Current Infectious Disease Reports·Jeanne M Marrazzo, Linda M Gorgos
Feb 2, 2013·Current Infectious Disease Reports·C A Muzny, J R Schwebke
Sep 23, 2006·The New England Journal of Medicine·Linda O Eckert
May 22, 2009·The Journal of Infectious Diseases·R Scott McClellandKing K Holmes
Dec 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Linda M Gorgos, Jeanne M Marrazzo
Dec 18, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeanne M Marrazzo
Mar 27, 2012·The Journal of Infectious Diseases·Jeanne M MarrazzoDavid N Fredricks
Feb 23, 2013·The Journal of Infectious Diseases·Jeanne M Marrazzo
Aug 5, 2009·Sexually Transmitted Diseases·Katherine E BungeSharon L Hillier
Aug 26, 2009·Sexually Transmitted Diseases·Orna ReichmanJack D Sobel
Apr 30, 2010·Sexually Transmitted Diseases·Jeanne M MarrazzoKathleen Ringwood
Nov 12, 2010·Sexually Transmitted Diseases·Jeanne M MarrazzoDavid N Fredricks
Jun 18, 2009·Current Opinion in Infectious Diseases·Phillip Hay
Oct 4, 2007·Sexually Transmitted Infections·Jeanne M Marrazzo
Dec 3, 2011·The Journal of Clinical Investigation·Rebecca M Brotman
Apr 12, 2014·Sexually Transmitted Diseases·Tina AguinJack D Sobel
Dec 12, 2013·Journal of Materials Science. Materials in Medicine·Vinay K SinghKrishna Pramanik
Aug 30, 2014·BMC Infectious Diseases·Rebecca M BrotmanJessica M Rath
Jul 4, 2012·Annual Review of Microbiology·Bing MaJacques Ravel
May 13, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B WangQ Liao
Jan 5, 2010·Journal of Women's Health·Judy Y ChenRichard H Beigi
Apr 4, 2015·Critical Reviews in Microbiology·Mathys Jacobus RedelinghuysMarleen Magdalena Kock
Dec 23, 2015·Critical Reviews in Microbiology·Bruna GonçalvesSónia Silva
Nov 19, 2010·Postgraduate Medicine·Martin Quan
Mar 4, 2014·Expert Opinion on Pharmacotherapy·Gilbert G G DondersDace Rezeberga
Apr 1, 2015·Sexual Medicine Reviews·Alison O Marshall
Dec 7, 2011·The American Journal of the Medical Sciences·David H Martin
Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Cameron BallKim A Woodrow

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