Suppressive effect of caffeine on hepatitis and apoptosis induced by tumor necrosis factor-alpha, but not by the anti-Fas antibody, in mice

Bioscience, Biotechnology, and Biochemistry
K SugiyamaP He

Abstract

Tumor necrosis factor (TNF)-alpha-induced hepatitis and apoptosis, as respectively assessed by serum enzyme activities and hepatic DNA fragmentation were effectively suppressed by a single force-feeding of caffeine (100 mg/kg) 1.5 h before injecting the drug. In contrast, caffeine had no significant effect on anti-Fas antibody-induced hepatitis and apoptosis. These results suggest that caffeine differentially affected TNF-alpha receptor- and Fas-mediated hepatitis and apoptosis.

References

Mar 10, 1995·Science·S Nagata, P Golstein
Feb 7, 1997·Cell·S Nagata
May 8, 1998·Bioscience, Biotechnology, and Biochemistry·K SugiyamaS Saeki
May 5, 1999·Bioscience, Biotechnology, and Biochemistry·S WadaK Sugiyama
Jul 8, 1999·The Journal of Nutrition·K SugiyamaS Saeki
Oct 8, 1999·Biological & Pharmaceutical Bulletin·M YoshikawaS Ishizaka
Jan 29, 2000·European Journal of Pharmacology·T Okamoto

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Citations

Oct 2, 2001·Bioscience, Biotechnology, and Biochemistry·P HeK Sugiyama

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