Suppressive effect of dietary resistant maltodextrin on systemic immunity in a mouse model of food allergy

Bioscience of Microbiota, Food and Health
Shoko MiyazatoAkira Hosono

Abstract

Resistant maltodextrin (RMD) is a soluble dietary fibre that exerts several physiological functions as a result of its microbial degradation and changes in the intestinal environment. It has been reported that RMD enhanced immunoglobulin A (IgA) secretion, which protects the mucosa from foreign substances. However, the effect of RMD on excessive immunity has yet to be investigated. In this study, we aimed to investigate the effect of RMD on excessive immune responses such as food allergy. OVA23-3 mice were fed an AIN-76-based diet containing 20% egg-white protein with or without RMD. While RMD was shown to contribute to an increase in goblet cells, RMD did not change the overall inflammatory status when ingested with the egg-white diet. RMD suppressed IL-4 and IL-10 production from splenocytes but not cells from mesenteric lymph nodes. RMD also downregulated the serum levels of OVA-specific Th1- and Th2-related antibodies, which were elevated in the food-allergic condition. RMD significantly increased the total amount of short-chain fatty acids, especially acetate and propionate, in the caecum of OVA23-3 mice fed the egg-white diet. Our study demonstrated that dietary RMD modulates systemic rather than intestinal antigen-specif...Continue Reading

References

Feb 1, 1995·Journal of Nutritional Science and Vitaminology·Y KishimotoH Takeda
May 6, 2006·The Journal of Allergy and Clinical Immunology·Haruyo Nakajima-AdachiShuichi Kaminogawa
Mar 27, 2007·European Journal of Nutrition·Yuka KishimotoDennis T Gordon
Jan 7, 2014·Nature Medicine·Aurélien TrompetteBenjamin J Marsland
Mar 15, 2018·Clinical and Experimental Gastroenterology·Norikazu WatanabeYukari Egashira

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Citations

Apr 9, 2020·Clinical and Molecular Allergy : CMA·Khui Hung LeeGuicheng Zhang

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Methods Mentioned

BETA
dissection
FCS
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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