Suppressive effect of elongation factor 2 on apoptosis induced by HIV-1 viral protein R

Apoptosis : an International Journal on Programmed Cell Death
S ZelivianskiR Y Zhao

Abstract

Rapid CD4+ lymphocyte depletion due to cell death caused by HIV infection is one of the hallmarks of acquired immunodeficiency syndrome. HIV-1 viral protein R (Vpr) induces apoptosis and is believed to contribute to CD4+ lymphocyte depletion. Thus, identification of cellular factors that potentially counteract this detrimental viral effect will not only help us to understand the molecular action of Vpr but also to design future antiviral therapies. In this report, we describe identification of elongation factor 2 (EF2) as such a cellular factor. Specifically, EF2 protein level is responsive to vpr gene expression; it is able to suppress Vpr-induced apoptosis when it is overproduced beyond its physiological level. EF2 was initially identified through a genome-wide multicopy suppressor search for Vpr-induced apoptosis in a fission yeast model system. Overproduction of fission yeast Ef2 completely abolishes Vpr-induced cell killing in fission yeast. Similarly, overexpression of the human homologue of yeast Ef2 in a neuroblastoma SKN-SH cell line and two CD4+ H9 and CEM-SS T-cell lines also blocked Vpr-induced apoptosis. The anti-apoptotic property of EF2 is demonstrated by its ability to suppress caspase 9 and caspase 3-mediated a...Continue Reading

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Citations

Sep 22, 2007·Apoptosis : an International Journal on Programmed Cell Death·Evi Derouet-HümbertMatthias Bureik
Apr 9, 2011·Molecular & Cellular Proteomics : MCP·Martin A BewleyDavid H Dockrell
Nov 15, 2014·Journal of Agricultural and Food Chemistry·Cheng LiuYu-Jen Wu
May 18, 2010·Journal of Proteomics·Angela van DiepenPeter W M Hermans
Mar 21, 2008·Cytokine & Growth Factor Reviews·Shai White-GilbertsonChristina Voelkel-Johnson
Apr 15, 2008·Biochimica Et Biophysica Acta·Esther OwsianowskiBirthe Fahrenkrog
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Sep 5, 2006·Biochemical and Biophysical Research Communications·Ying ZhangRichard Y Zhao
Mar 18, 2016·PloS One·Zsigmond BenkoRichard Y Zhao
Feb 15, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Richard Y ZhaoMichael I Bukrinsky
Jan 18, 2017·Cell & Bioscience·Zsigmond BenkoRichard Y Zhao
Dec 5, 2008·Journal of Proteome Research·Ramamurthy NarayanNicole Zitzmann

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