PMID: 9430602Jan 31, 1998Paper

Suppressive effect of globin digest on postprandial hyperlipidemia in male volunteers

The Journal of Nutrition
K KagawaH Okuda

Abstract

We have reported previously that various edible protein digests inhibit dietary hyperlipidemia in mice, rats, pigs and dogs. Of the various digests tested, globin digest had the most potent inhibitory activity, and a tetrapeptide extracted from globin digest, Val-Val-Tyr-Pro, had activity 7000-fold greater than that of the parent digest. In this clinical study, we investigated the influence of globin digest on serum chylomicron triglyceride concentrations as an indicator of the effect of globin digest on fat absorption and catabolism in humans. Parallel and crossover trials were conducted in which men consumed a control high fat diet (25 g fat, 7.6 g carbohydrate, 1.9 g protein and 0.7 g sodium chloride) or the same diet supplemented with globin digest. The supplemented dosages were 1 and 4 g globin digest. In the parallel trial, 22 men were divided into three groups: control, globin digest 1 g and globin digest 4 g. The increases in chylomicron triglyceride concentrations at 1 h after ingestion of 1 or 4 g globin digest were significantly lower (P < 0.05) compared with the control group. The crossover trial involved six subjects who consumed the control high fat diet and the same diet supplemented with 4 g globin digest. Serum...Continue Reading

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Jan 5, 2007·Journal of Medicinal Food·Andrew RobertsFrank Greenway
Jan 22, 2010·Nutrition Research and Practice·Joohee KimMi Kyung Kim
Dec 18, 2013·Bioprocess and Biosystems Engineering·K HedhiliN Nedjar-Arroume
Dec 3, 2016·Animal Science Journal = Nihon Chikusan Gakkaihō·Masanori KatsumuraHiroshi Kamisoyama
Jul 30, 2019·Journal of Food Biochemistry·Satoshi Nagaoka
May 29, 2008·European Journal of Nutrition·Niels Peter MöllerJürgen Schrezenmeir
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Aug 28, 2021·International Journal of Molecular Sciences·Il-Sup KimCheorl-Ho Kim

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