PMID: 9445387Mar 7, 1998Paper

Suppressive effect of insulin on the synthesis of sucrase-isomaltase complex in small intestinal epithelial cells, and abnormal increase in the complex under diabetic conditions

The Biochemical Journal
M TakenoshitaY Nakano

Abstract

An abnormally high level of the sucrase-isomaltase (SI) complex in the small intestine of rats with streptozotocin-induced insulin-dependent diabetes mellitus (IDDM) was normalized in 11 h by the administration of insulin, in addition to normalization of the blood glucose level. Phlorizin, an inhibitor of renal glucose reabsorption, also caused normalization of the blood glucose level in the IDDM rats; however, the level of the SI complex was barely changed. When mucosa explants were cultured in a medium, the SI complex synthesized during the cultivation was accumulated as its precursor protein without maturation, owing to the absence of pancreatic proteases, and the amount of the precursor protein that accumulated in the explants was decreased by the addition of insulin into the medium. Further, the mRNA level of the SI complex in the explants incubated with insulin was obviously lower than that in the absence of insulin. These results indicate that insulin has a suppressive effect on the synthesis of the SI complex, presumably by decreasing the transcriptional level of the gene encoding the complex, in small-intestinal epithelial cells. Thus the synthesis of the SI complex might exceed normal levels in the epithelial cells as...Continue Reading

Citations

Mar 10, 2001·The American Journal of Clinical Nutrition·G F MeloniT Meloni
Mar 4, 2005·Molecular Nutrition & Food Research·Rashmi RamachandraParamahans V Salimath
Jul 19, 2005·The British Journal of Nutrition·Keiichiro SugimotoYoshihisa Nakano
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·E J Kelly, I R Sanderson
Oct 4, 2011·Molecular and Cellular Biochemistry·Ruchi SharmaAkhtar Mahmood
Aug 15, 2000·Annual Review of Nutrition·I R Sanderson, S Naik
Nov 4, 2004·Biochemical and Biophysical Research Communications·Ning GuKoichiro Yasuda
Feb 8, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hsien-Tsung YaoMeng-Tsan Chiang

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