Suppressive effect of Kanzo-bushi-to, a Kampo medicine, on collagen-induced arthritis

Biological & Pharmaceutical Bulletin
Yuka OnoYukio Ogihara

Abstract

Kanzo-bushi-to (KBT) is a traditional Japanese herbal medicine (Kampo medicine), which is used in Japan to treat rheumatoid arthritis. In the present study, we investigated the suppressive effect of KBT on collagen-induced arthritis (CIA) and further studied the underlying mechanism. CIA was induced in male DBA/1J mice by immunization with bovine type II collagen, followed by a booster injection 21 d later. KBT was given at a dose of 430 mg/kg/d from three days before the first immunization to the end of the experiment. KBT suppressed CIA development effectively and further protected focal bone erosion and bone destruction as evidenced by the reduced histological score. Histochemical examination revealed that KBT decreased TRAP-positive cells at the synovium-bone interface and at the sites of focal bone erosion, coincident with the findings that RANKL/OPG mRNA ratio was significantly reduced by KBT treatment. KBT also decreased mRNA levels of M-CSF and iNOS in joints and of iNOS in peritoneal macrophages. In conclusion, KBT prevented osteoclast generation by decreasing RANKL/OPG ratio and M-CSF mRNA levels, resulting in reduction in bone erosion and destruction. In addition, KBT has anti-inflammatory effect such as the suppress...Continue Reading

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Citations

Feb 11, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·O Gon KwonYoung Joon Lee
Jul 2, 2008·Biological & Pharmaceutical Bulletin·Jee-Hun ParkHee Kang
Jun 12, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhe ChenYi Jiang
Jul 26, 2008·International Immunopharmacology·Mei LiuZhunan Gong
Oct 11, 2011·International Immunopharmacology·Mingqiang LiuPeifeng Li
Mar 21, 2013·European Journal of Pharmacology·Lei LiPeifeng Li
Nov 15, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·A-Ram KimWahn Soo Choi

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