Suppressive effect of recombinant human thioredoxin on ultraviolet light-induced inflammation and apoptosis in murine skin

The Journal of Dermatology
Ryusuke OnoChikako Nishigori

Abstract

Thioredoxin (TRX) is a small ubiquitous protein, which regulates cellular redox status and scavenges reactive oxygen species. The present study was conducted to investigate the effect of TRX on ultraviolet (UV)-B-mediated inflammatory and apoptotic responses. Ear swelling after UV-B irradiation was significantly reduced in TRX-transgenic mice compared to wild-type mice. Administration i.p. of recombinant human TRX also reduced acute skin inflammatory reaction, such as skin erythema and swelling. Histologically, numbers of inflammatory cells including neutrophils and lymphocytes were significantly reduced and the average size of the caliber of blood vessels were also reduced in recombinant human TRX-injected mice. The number of apoptotic keratinocytes, in terms of sunburn cells, activated-caspase-3-positive cells and terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells were all significantly reduced in recombinant human TRX-injected mice. Immunohistochemical intensity of 8-hydroxy-2'-deoxyguanosine was strikingly reduced in recombinant human TRX-injected mouse. Western blotting showed that administration of recombinant human TRX attenuated duration of phosphorylation of p38 mitogen-activated protein kinase...Continue Reading

References

Aug 14, 1992·Biochemical and Biophysical Research Communications·A MitsuiJ Yodoi
Aug 15, 1989·Archives of Biochemistry and Biophysics·R A FloydJ E Schneider
Jan 1, 1988·The British Journal of Dermatology·J L HawkC A Holden
Jan 1, 1985·Annual Review of Biochemistry·A Holmgren
Aug 22, 1996·Nature·D B HallJ K Barton
Jan 1, 1996·Free Radical Biology & Medicine·Y Sun, L W Oberley
Feb 3, 1998·Journal of the American Academy of Dermatology·B Eberlein-KönigB Przybilla
Jun 20, 1998·The Journal of Biological Chemistry·T KuwanaS Kornbluth
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y TakagiJ Yodoi
May 18, 1999·Biochemical and Biophysical Research Communications·S HashimotoT Horie
Sep 30, 2000·European Journal of Biochemistry·E S Arnér, A Holmgren
Oct 18, 2000·Biochemical and Biophysical Research Communications·K C Das, C K Das
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·H NakamuraJ Yodoi
Jun 21, 2003·American Journal of Respiratory and Critical Care Medicine·Tomoaki HoshinoJunji Yodoi
Aug 22, 2003·Photochemistry and Photobiology·Tae-Heung KimStephen E Ullrich
Jul 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ling TaoXin L Ma
Mar 8, 2005·Mutation Research·Jean CadetThierry Douki
Jun 16, 2005·The Journal of Investigative Dermatology·Arianna L KimDavid R Bickers
Jul 2, 2005·Trends in Pharmacological Sciences·Anne Burke-GaffneyHajime Nakamura
May 6, 2006·Cell Death and Differentiation·C GarridoG Kroemer
Oct 19, 2006·Pulmonary Pharmacology & Therapeutics·Tadaaki YamadaJunji Yodoi
Jul 27, 2007·Free Radical Research·Aiguo TanJunji Yodoi
Dec 19, 2007·Photochemistry and Photobiology·Wolfgang Köpcke, Jean Krutmann
Jan 16, 2008·Photochemistry and Photobiology·Joyce E Rundhaug, Susan M Fischer
Jul 16, 2010·The Biochemical Journal·Ana Cuadrado, Angel R Nebreda

❮ Previous
Next ❯

Citations

Dec 19, 2012·Antioxidants & Redox Signaling·Dler Faieeq Darweesh MahmoodMustapha Rouis
Mar 12, 2013·Journal of Bioscience and Bioengineering·Yu Jae HyunJin Won Hyun
Feb 14, 2013·Cytokine & Growth Factor Reviews·Yoshiyuki Matsuo, Junji Yodoi
Apr 16, 2014·The Journal of Investigative Dermatology·Flandiana YogiantiChikako Nishigori
Apr 21, 2016·Archives of Biochemistry and Biophysics·Junji YodoiHajime Nakamura
Sep 8, 2016·Journal of Cancer Research and Clinical Oncology·Maryam SobhaniSeyed Isaac Hashemy
May 22, 2017·The Journal of Investigative Dermatology·Makoto KunisadaChikako Nishigori
Sep 13, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mayumi HatakeyamaChikako Nishigori
Jul 16, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Chikako Nishisgori
Jan 23, 2021·Photochemistry and Photobiology·Nozomi YamanoChikako Nishigori

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis