PMID: 6161219Aug 1, 1980Paper

Suppressive effect of triethyllead on entry of proteins into the CNS myelin sheath in vitro

Journal of Neurochemistry
G Konat, J Clausen

Abstract

Incorporation of [14C]leucine into the myelin sheath was studied in brain stem slices prepared from 22-day-old rats. Individual major myelin proteins were separated by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulphate. There was a time lag before incorporation of the label into proteolipid protein (PLP) and intermediate protein (IP) reached maximal rates. Labelling of basic proteins (BP) and Wolfgram proteins (WP) revealed a much shorter lag in entry. Appearance of radioactive proteins in the myelin sheath was significantly hampered by triethyllead (PbEt3) added to the incubation medium at micromolar concentrations. Inhibition values were highest in the case of PLP and were closely followed by the values for IP. BP and WP were less inhibited, although incorporation of these proteins into myelin was still suppressed more than was synthesis of total homogenate protein. Thus, myelin -forming cells seem to be unduly vulnerable to the toxin relative to the rest of the tissue. Furthermore, the results indicate an interference of PbEt3 with certain posttranslational process involved in furnishing of integral myelin proteins.

References

Jun 1, 1975·Journal of Neurochemistry·J A BenjaminsP Morell
Feb 25, 1977·Science·J E Rothman, J Lenard
Mar 1, 1978·Experimental Neurology·G KonatJ Clausen
Oct 1, 1978·Journal of Neurochemistry·J A BenjaminsJ Hazlett
Aug 1, 1976·Journal of Neurochemistry·J A BenjaminsP Morell
Dec 1, 1975·Journal of Neurochemistry·E A Lock, W N Aldridge
Jan 1, 1973·Immunological Communications·R M HerndonE R Einstein
Apr 1, 1974·The Biochemical Journal·H C AgrawalR F Mitchell
Apr 23, 1974·Biochemical and Biophysical Research Communications·J L NussbaumP Jollès
Sep 1, 1972·Journal of Neurochemistry·H C AgrawalA L Prensky

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Citations

Jan 1, 1984·Acta Neuropathologica·N J Ferris, B G Cragg
Dec 1, 1986·Metabolic Brain Disease·G KonatE L Hogan
Jun 1, 1987·Metabolic Brain Disease·G KonatE L Hogan
Jan 1, 1986·Neurochemistry International·G KonatE L Hogan
Jan 1, 1987·Neurochemistry International·G KonatI Singh
Jan 1, 1985·Progress in Neurobiology·G Audesirk
May 1, 1985·Journal of Neurochemistry·G KonatR C Wiggins
Jun 1, 1993·Acta Neurologica Scandinavica·J Clausen
Jan 7, 2004·Brain Research·Alicja Krasowska, Gregory W Konat
Jan 1, 1982·Experimental Neurology·G Konat, H Offner

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