Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma

International Immunopharmacology
Sei-Ryang OhHyeong-Kyu Lee

Abstract

Allergic inflammation of the airways has a critical role in asthma development. We investigated a suppressive effect of verproside (3,4-dihydroxy catalpol) isolated from the extract of Pseudolysimachion longifolium on asthmatic parameters--such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness and mucus hypersecretion--in an OVA-sensitized/challenged mouse model. Verproside significantly inhibited the increase of total IgE and the cytokines IL-4 and IL-13 in plasma and bronchoalveolar lavage fluid, and also effectively suppressed airway hyperresponsiveness, eosinophilia and mucus hypersecretion in OVA-induced asthmatic mice. The efficacy of verproside was comparable to montelukast, an anti-asthmatic drug that is currently available. These results suggest that verproside could be a major marker in herbal medicines that are used for asthma treatment, and could also act as a lead for anti-asthmatic drugs.

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Citations

Feb 23, 2012·Inflammopharmacology·Rania R Abdel AzizNariman M Gameil
May 2, 2009·Archives of Pharmacal Research·Eun Jeong ParkHye Suk Lee
Nov 17, 2011·International Immunopharmacology·Mee-Young LeeSei-Ryang Oh
Feb 8, 2011·International Immunopharmacology·Ju-Young JungHwa-Young Son
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Jun 21, 2019·Current Medicinal Chemistry·Liu-Qiang ZhangYi-Ming Li
Jan 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Congcong WangMinhui Li
Oct 23, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min Gi KimHye Suk Lee
Jun 11, 2015·Inflammation·Jiping LiuShiping Ma

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