Suppressive Effects of Bee Venom Acupuncture on Paclitaxel-Induced Neuropathic Pain in Rats: Mediation by Spinal α₂-Adrenergic Receptor

Toxins
Jiho ChoiSun Kwang Kim

Abstract

Paclitaxel, a chemotherapy drug for solid tumors, induces peripheral painful neuropathy. Bee venom acupuncture (BVA) has been reported to have potent analgesic effects, which are known to be mediated by activation of spinal α-adrenergic receptor. Here, we investigated the effect of BVA on mechanical hyperalgesia and spinal neuronal hyperexcitation induced by paclitaxel. The role of spinal α-adrenergic receptor subtypes in the analgesic effect of BVA was also observed. Administration of paclitaxel (total 8 mg/kg, intraperitoneal) on four alternate days (days 0, 2, 4, and 6) induced significant mechanical hyperalgesic signs, measured using a von Frey filament. BVA (1 mg/kg, ST36) relieved this mechanical hyperalgesia for at least two hours, and suppressed the hyperexcitation in spinal wide dynamic range neurons evoked by press or pinch stimulation. Both melittin (0.5 mg/kg, ST36) and phospholipase A2 (0.12 mg/kg, ST36) were shown to play an important part in this analgesic effect of the BVA, as they significantly attenuated the pain. Intrathecal pretreatment with the α₂-adrenergic receptor antagonist (idazoxan, 50 µg), but not α₁-adrenergic receptor antagonist (prazosin, 30 µg), blocked the analgesic effect of BVA. These results ...Continue Reading

References

Jan 1, 1991·Progress in Brain Research·S L Jones
Apr 8, 2003·The Journal of Veterinary Medical Science·Hyun-Woo KimJang-Hern Lee
Aug 12, 2004·Neuroreport·Wen-Ching LiuBarry R Komisaruk
Jan 5, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hyun Woo KimJang Hern Lee
Apr 1, 2005·The New England Journal of Medicine·Ian GilronRobyn L Houlden
Jan 13, 2006·Neuroscience Letters·Sarah J L FlattersGary J Bennett
Apr 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James J Lee, Sandra M Swain
Jun 15, 2007·Research in Veterinary Science·Chang Shik YinHyeong Gyun Koh
Jan 30, 2008·The Journal of Pain : Official Journal of the American Pain Society·Myeong Soo LeeEdzard Ernst
Mar 11, 2008·Critical Reviews in Oncology/hematology·Andreas A ArgyriouHaralabos P Kalofonos
Jan 27, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·John GoffinUNKNOWN Lung Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-Based Care
Jun 19, 2010·Progress in Neurobiology·Jun Chen, William R Lariviere
Jul 24, 2010·Lancet Neurology·Ralf BaronGunnar Wasner
May 29, 2012·Parkinsonism & Related Disorders·Seung-Yeon ChoSeong-Uk Park
Aug 18, 2012·Journal of Acupuncture and Meridian Studies·Jeungwon YoonHwa-Seung Yoo
Mar 8, 2013·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Aaron I Vinik, Carolina M Casellini
Sep 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Bong-Soo LimByung-Il Min
Dec 11, 2013·Anesthesiology·Ruixin ZhangBrian M Berman
Apr 27, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li LinLiang Cai

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Mar 17, 2018·Toxins·Steve Peigneur, Jan Tytgat
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Dec 29, 2020·Frontiers in Public Health·Keneth Iceland KasoziSusan Christina Welburn
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