Suppressive effects of bee venom on the immune responses in collagen-induced arthritis in rats

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Kyung-Woon KimCheorl-Ho Kim

Abstract

The effect of bee venom (BVA) on the development of type II collagen (CII)-induced arthritis (CIA) in rats has been studied. Male rats were immunized with an emulsion of 200 microg of CII and complete Freund's adjuvant (CFA). The rats were then given intraperitoneally (i.p.) injection of a suspension of BVA or saline during the experiment. The effect of BVA on cellular responses to CII was examined. In the control rats, the onset of arthritis was observed at the 24th day after the CII-immunization, and the severity of CIA was developed gradually. As compared with rats treated with saline, BVA i.p. injected at doses of more than 20 microl/100g mouse once a day for 14 days inhibited the ability of inguinal lymph node cells to produce T cell cytokines interleukin-1beta, -2, -6, tumor necrosis factor-alpha and interferon-gamma when the cells were obtained from rats 24 days after immunization and cultured in vitro with CII. When rats were injected i.p. with sheep red blood cells, hemagglutination titers in BVA-treated and control rats did not differ significantly when low doses of BVA was given to rats. However, i.p. injection of BVA at doses of more than 10 microl/100g/day suppressed antibody production. Pretreatment of rats with B...Continue Reading

References

Sep 1, 1977·The Journal of Experimental Medicine·D E TrenthamA H Kang
Aug 1, 1992·International Journal of Immunopharmacology·S X YangZ Z Long
Jan 1, 1987·Arthritis and Rheumatism·M E WeinblattK F Austen
Sep 1, 1994·British Journal of Rheumatology·N A Staines, P H Wooley
Aug 1, 1996·Pain·W R Lariviere, R Melzack

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Citations

Dec 18, 2013·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Latifeh KarimzadehAzar Sheikholeslami
Mar 5, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Xiaolu FengKexuan Tang
Sep 16, 2008·Journal of Ethnopharmacology·Han-Sung LeeJong-Soo Lee

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