Suppressive effects of long-term exposure to P-nitrophenol on gonadal development, hormonal profile with disruption of tissue integrity, and activation of caspase-3 in male Japanese quail (Coturnix japonica)

Environmental Science and Pollution Research International
Eman AhmedGen Watanabe

Abstract

P-Nitrophenol (PNP) is considered to be one of nitrophenol derivatives of diesel exhaust particles. PNP is a major metabolite of some organophosphorus compounds. PNP is a persistent organic pollutant as well as one of endocrine-disrupting compounds. Consequently, bioaccumulation of PNP potentiates toxicity. The objectives of the current study were to assess in vivo adverse effects of long-term low doses of PNP exposure on reproductive system during development stage. Twenty-eight-day-old male Japanese quails were orally administered different doses of PNP (0, 0.01, 0.1, 1 mg/kg body weight) daily for 2.5 months. Testicular histopathology, hormones, caspase-3 (CASP3), and claudin-1 (CLDN1) tight junction protein, as well as plasma hormones were analyzed. The results revealed that long-term PNP exposure caused testicular histopathological changes such as vacuolation of spermatogenic cell and spermatocyte with significant testicular and cloacal gland atrophy. PNP activated CASP3 enzyme that is an apoptosis-related cysteine peptidase. Besides, it disrupted the expression of CLDN1. Furthermore, a substantial decrease in plasma concentrations of luteinizing hormone (LH) and testosterone was observed after 2 and 2.5 months in the PNP-...Continue Reading

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Citations

Oct 27, 2017·Animal : an International Journal of Animal Bioscience·X Y ZhangH Li
Feb 15, 2018·Environmental Science and Pollution Research International·Hazem EmamMohamed Abdel-Daim
Nov 8, 2020·General and Comparative Endocrinology·Shanmao RenChunmei Li
Apr 14, 2021·Environmental Science and Pollution Research International·Eman A AhmedAhmed K Elsayed
Apr 25, 2021·Environmental Monitoring and Assessment·Ailton José MoreiraGian Paulo Giovanni Freschi

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Methods Mentioned

BETA
light microscopy

Software Mentioned

GraphPad Prism

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