Suppressive levothyroxine therapy has no significant influence on bone degradation in women with thyroid carcinoma: a comparison with other disorders affecting bone metabolism

Thyroid : Official Journal of the American Thyroid Association
P MikoschP Lind

Abstract

The aim of this study was to examine different influences on bone degradation (estrogen status, thyroid function, parathyroid function, bone metastases) with special interest focusing on the significance of suppressive levothyroxine therapy (LT4) on bone degradation in patients with differentiated thyroid carcinoma (DTC). Two markers of bone degradation (ELItest NTx = U-NTx; Serum CrossLaps = S-CTx) were used (1) to quantify the influence of different metabolic influences on bone degradation and (2) to compare these two markers with each other. One hundred forty samples of 98 female patients ages 23-86 years were analyzed. The correlation between the two assays of bone degradation was high (r = 0.825; p < 0.001). Both assays demonstrated that estrogen deficiency, hyperparathyroidism, and bone metastases caused significant increases of bone degradation. A suppressive LT4 therapy, as used for patients with DTC, led to no significant increases of S-CTx and U-NTx. The study indicates that a well-controlled suppressive LT4 therapy has only a minor effect on the degree of bone degradation and that a possible estrogen deficiency in patients with DTC has a greater impact on bone degradation. Thus, female patients with DTC on suppressiv...Continue Reading

References

Jun 12, 1995·Archives of Internal Medicine·L Wartofsky
Apr 27, 1994·JAMA : the Journal of the American Medical Association·D L SchneiderD J Morton
May 1, 1997·Calcified Tissue International·S L GreenspanL Ferguson
Jul 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M BondeC Christiansen
May 20, 1998·Journal of Clinical Laboratory Analysis·M ZaninottoM Plebani
May 13, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H W WoitgeM J Seibel
Jun 5, 1999·Annals of Internal Medicine·S L Greenspan, F S Greenspan
Sep 3, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TakamiA Carpi
Oct 19, 1999·Thyroid : Official Journal of the American Thyroid Association·P MikoschP Lind
Aug 6, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E FinkJ C Souberbielle

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Citations

Jun 14, 2003·Thyroid : Official Journal of the American Thyroid Association·P MikoschP Lind
Nov 25, 2003·Cancer Biotherapy & Radiopharmaceuticals·Jason B CohenI Ross McDougall
Jul 15, 2006·Thyroid : Official Journal of the American Thyroid Association·K A HeemstraJ W A Smit
Feb 28, 2008·Thyroid : Official Journal of the American Thyroid Association·Peter MikoschPeter Pietschmann
Aug 18, 2012·International Journal of Endocrinology·Sandro La VigneraAldo E Calogero
Aug 4, 2007·Endocrinology and Metabolism Clinics of North America·Jason A Wexler, John Sharretts
Aug 9, 2006·European Journal of Clinical Investigation·P MikoschP Pietschmann
Sep 9, 2017·Current Medical Research and Opinion·Shih-Yi LinChia-Hung Kao

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