PMID: 6972570Jan 1, 1980Paper

Suppressor activity of T cells bearing Fc receptors for IgG on lymphoid colony formation

Scandinavian Journal of Immunology
G W CanonicaL Moretta


Human T lymphocytes, upon phytohaemagglutinin stimulation, are able to form colonies in semisolid media. Peripheral T cell bearing Fc receptors (TG) were studied for their possible regulatory activity on lymphoid colony development. Although no substantial differences were observed between the cloning efficiency of unfractionated T cells (thus including TG cells) and T cells depleted of TG, a sharp suppression of colony formation occurred when positively selected TG cells were readded to TG-depleted suspensions. Therefore, TG suppressor activity seems to be strictly dependent upon cell interaction with ox IgG immune complexes used for TG cell isolation. Different experimental approaches failed to demonstrate, although did not exclude, that suppression in this system is mediated by soluble factors. gamma-irradiation of TG cells abrogated their suppressor capacity.


Jan 1, 1979·Immunological Reviews·R E BallieuxB J Zegers
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Jan 1, 1979·Immunological Reviews·L MorettaA Moretta
Apr 1, 1980·The Journal of Experimental Medicine·E L ReinherzS F Schlossman

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Jan 1, 1982·Springer Seminars in Immunopathology·M C MingariL Moretta
Apr 1, 1983·Journal of Endocrinological Investigation·M BagnascoO Ferrini
Jun 1, 1982·Clinical Immunology and Immunopathology·G W CanonicaG Giordano
Jul 1, 1983·Clinical Immunology and Immunopathology·J TarkkanenM Paavolainen
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May 1, 1984·Scandinavian Journal of Immunology·G Sønderstrup-HansenM H Claësson
Apr 1, 1984·Journal of Endocrinological Investigation·P BiassoniM Bagnasco

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