PMID: 42840Sep 1, 1979

Suppressor adherent phagocytic cells in solid tumors: a postulated escape mechanism

Medical Hypotheses
R C Parks

Abstract

A localized graft-versus-host reaction was used to assess the cellular immunity of mice supporting progressive growth of an allogeneic tumor. It was found that early in tumor development anti-tumor-cellular-mediated immunity was hyper-responsive, and that adherent phagocytic cells isolated from the neoplasm would inhibit the specific immunological response. Based on these observations and indirect inference it was postulated that a major factor in the success of an immunogenic tumor is the coterminous development of a normal adherent phagocytic cell population which specifically nullifies, in situ, cellular-mediated anti-tumor immunity.

References

Jan 1, 1985·Cancer Investigation·C N BarreraC D Pasqualini

Citations

Oct 1, 1977·The Journal of Clinical Investigation·A W Hamburger, S E Salmon
Jan 1, 1978·Immunological Reviews·E R Unanue
Jul 29, 1977·Science·A W Hamburger, S E Salmon
Dec 1, 1976·The Journal of Experimental Medicine·M Cancro, M Potter
Mar 30, 1974·Cellular Immunology·S G Rice, M Fishman
Oct 1, 1972·Transplantation·R Evans
May 14, 1927·British Medical Journal·H T Deelman

Related Concepts

Neoplasms
Neoplasm Transplantation
Graft Vs Host Reaction
Cell Adhesion
Brachydactyly
Transplantation, Homologous
Phagocytosis
Tumor Antigens
Neoplasms, Experimental

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