PMID: 197528Jul 1, 1977Paper

Suppressor cell regulation of immune response to tumors: abrogation by adult thymectomy

Proceedings of the National Academy of Sciences of the United States of America
C L ReinischS F Schlossman

Abstract

The regulatory role of the adult thymus on the appearance of cytotoxic and suppressor T cells (thymus-derived lymphocytes) to allogeneic and autochthonous virus-induced tumors in mice was investigated. It was demonstrated that C57BL/6 mice challenged with allogeneic P815 mastocytoma cells and complete Freund's adjuvant failed to develop cytotoxic cells but instead developed suppressor T cells which inhibited cytotoxic T cell function. Further, adjuvant-induced suppressor cells prevented the primary in vitro induction of cytotoxic T cells to P815 mastocytoma cells. In contrast, adult thymectomized animals, when challenged with adjuvant and allogeneic cells, had a normal cytotoxic response in vivo and their cells could not inhibit the generation of cytotoxic T cells in vitro. These studies suggested that the intact adult thymus was necessary for the induction of suppressor cells. Moreover, suppressor cells regulated cytotoxic T cell activity both in vivo and in vitro. Further, it was shown that adjuvant could prevent the normal immune response to virus-induced tumors. BALB/c mice treated with murine sarcoma virus developed tumors which reached a maximal size by day 14 and then regressed. Sham thymectomized animals treated with vi...Continue Reading

References

Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·H Cantor, E A Boyse
Jan 1, 1975·Transplantation Reviews·D NachtigalM Feldman
Feb 1, 1972·The Journal of Experimental Medicine·O StutmanR A Good

Citations

Feb 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·A S Babadzhanov, E G Slavina
Jan 1, 1983·Developmental and Comparative Immunology·R Mattsson
Jan 1, 1981·Comparative Immunology, Microbiology and Infectious Diseases·T G SniderK R Pierce
Dec 14, 1978·The New England Journal of Medicine·S Broder, T A Waldmann
May 10, 1979·The New England Journal of Medicine·E L ReinherzS F Schlossman
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A J StrelkauskasS F Schlossman
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I HellströmI D Bernstein
Aug 1, 1978·The Journal of Experimental Medicine·C L Reinisch, S L Andrew
Sep 1, 1978·The Journal of Experimental Medicine·K E HellströmJ D Tamerius
Mar 1, 1983·The Journal of Clinical Investigation·J A SaryanR S Geha
Jan 1, 1985·Critical Reviews in Oncology/hematology·R S Schulof
Dec 1, 1979·Cellular Immunology·S L AndrewC L Reinisch
Sep 14, 1978·Nature·I Hellström, K E Hellström
Jun 15, 1981·International Journal of Cancer. Journal International Du Cancer·M PratP M Comoglio

Related Concepts

Tumor Antigens
Microcytotoxicity Test
Freund's Adjuvant
SD Antigens
Cellular Immune Response
Therapeutic Immunosuppression
Mice, Inbred Strains
Finkel-Biskis-Reilly murine sarcoma virus
Rhabdomyosarcoma
Sarcoma, Jensen

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