PMID: 6290745Aug 1, 1982Paper

Suppressor cells assayed by numerical and functional tests in chronic renal failure

Kidney International
J E LortanY K Seedat

Abstract

Suppressor cells were assayed by numerical and functional tests in adults on chronic hemodialysis. Peripheral blood mononuclears (PBM) were classified as total T-cells by E-rosettes and by the monoclonal antibody OKT3, as T-cell subsets by OKT4 (inducer/helper T-cells) and OKT8 (cytotoxic/suppressor T-cells) and as B-cells by the presence of surface immunoglobulin. The suppressive effect of PBM pretreated with either Concanavalin A (Con A), sodium periodate, or serum rich in immune complexes, on normal homologous phytohemagglutinin (PHA) lymphocyte transformation, was determined. Usual tests of T-cell function were not done. T lymphopenia was due to significant diminution (P less than 0.002) in numbers of OKT4+ cells in patients (516 +/- 44 cells/mm3, mean +/- sem) as compared to controls (906 +/- 96 cells/mm3). The number of OKT8+ cells in patients was not different from normal although their percentage (45 +/- 4%) was slightly higher than controls (36 +/- 5%) (P less than 0.10). Suppressor activity using only a suboptimal dose of Con A (5 micrograms/ml), was significantly lower (P less than 0.002) in uremic patients (36 +/- 12%) than in controls (67 +/- 7%). An important finding was that no significant correlations were detec...Continue Reading

References

Jan 1, 1976·Nephron·H Dobbelstein
May 1, 1976·The Journal of Experimental Medicine·L ShouR A Good
Nov 8, 1979·The New England Journal of Medicine·E L ReinherzS F Schlossman
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Nov 1, 1975·Cellular Immunology·D P SengarJ E Harris
Nov 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A Novogrodsky, E Katchalski
Apr 1, 1980·Cell·E L Reinherz, S F Schlossman
Mar 22, 1957·Annals of the New York Academy of Sciences·G J DAMMINJ E MURRAY

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Citations

Nov 1, 1983·The American Journal of Medicine·K RaskaL Homer
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·L MorraG Bessone
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L ChatenoudJ F Delfraissy
Jan 1, 1987·Scandinavian Journal of Infectious Diseases·P KiepielaP Coward
Jun 1, 1986·Kidney International·P KurzK H Meyer zum Büschenfelde
Oct 1, 1983·The American Journal of Medicine·M C RuddyK H Stenzel
Feb 1, 1992·Clinical and Experimental Immunology·S IkemotoM Maekawa
Jul 3, 2018·Frontiers in Immunology·María MolinaEnrique Morales
Dec 1, 1989·Annals of Tropical Paediatrics·P KiepielaP Becker

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