Jan 1, 1976

Suppressor cells in the embryonic thymus mediate allograft tolerance

Advances in Experimental Medicine and Biology
W Droege, M Tuneskog


Thymus cells from non-immunized young chickens suppress the allograft rejection in lightly irradiated syngeneic or allogeneic recipients and mediate longlasting skingraft survival in a significant proportion of recipients across a strong histocompatibility difference. Suppressive activity of this kind is already found in the embryonic thymus and is therefore believed to mediate also self tolerance and neonatal allograft tolerance.

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Mentioned in this Paper

Lymphoid Cells
Graft Vs Host Reaction
Therapeutic Immunosuppression
Graft Rejection
Chick Embryo
Transplantation, Homologous
Age Factors

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