Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus

The Journal of Clinical Investigation
B Bresnihan, H E Jasin

Abstract

Normal peripheral blood mononuclear cells demonstrated increased DNA synthesis and secretion of newly synthesized protein when suboptimal concentrations of Concanavalin A (Con A) were added to the cultures after 24-h incubation in vitro. Cells stimulated by Con A, 1 mug/ml, after 24-h incubation demonstrated 3.0 times more tritiated thymidine incorporation, and 4.4 times more 14C-amino acid incorporation into newly synthesized secreted protein, than cells stimulated at 0 h (P less than 0.001). The acquisition of increased responsiveness was not abrogated by washing and resuspending the cells in fresh medium. Since the increased responsiveness could be inhibited by the addition to the cultures of small numbers of cells previously activated by Con A it is suggested that the enhanced reactivity acquired in culture represents the loss of a subpopulation of suppressor cells that modulate the T-lymphocyte response. Cells from nine patients with active, untreated systemic lupus erythematosus demonstrated normal responses to optimal concentrations of Con A added at 0 h, but an impaired response to Con A, 1 mug/ml. When these cells were incubated for 24 h, a significant increased response to Con A was not observed. This observation sugg...Continue Reading

References

Nov 1, 1975·Transplantation·D SampsonH M Kauffman
May 1, 1976·The Journal of Experimental Medicine·L ShouR A Good
May 1, 1975·Arthritis and Rheumatism·H E Jasin, M Ziff
Feb 1, 1976·The Journal of Clinical Investigation·J D StoboP E Hermans
Jul 1, 1974·The Journal of Experimental Medicine·A BastenC Cheers
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J Andersson, F Melchers
Jun 1, 1972·European Journal of Immunology·O Sjöberg, S Britton
Jan 1, 1972·Transplantation Reviews·J AnderssonG Möller

❮ Previous
Next ❯

Citations

Jun 1, 1978·Arthritis and Rheumatism·J B WinfieldA Singer
Jan 1, 1979·Arthritis and Rheumatism·M E Hamilton, J B Winfield
Jul 1, 1979·Arthritis and Rheumatism·T SakaneI Green
Sep 1, 1979·Arthritis and Rheumatism·G BiberfeldP Biberfeld
Jan 1, 1984·Archives of Oto-rhino-laryngology·G Siegel
Mar 1, 1984·Journal of Clinical Immunology·R C WilliamsT J Spira
Oct 1, 1981·Journal of Clinical Immunology·G C Tsokos, J E Balow
Sep 1, 1988·Journal of Clinical Immunology·M R LieblingJ S Louie
Jan 1, 1990·Archives of Environmental Contamination and Toxicology·R M BauerR G Olsen
Feb 1, 1980·Digestive Diseases and Sciences·R K Zetterman, J A Woltjen
Sep 1, 1981·Digestive Diseases and Sciences·R M Victorino, H J Hodgson
Apr 1, 1983·Digestive Diseases and Sciences·M G MutchnickA L Goldstein
Jan 1, 1985·Heart and Vessels. Supplement·B Maisch, T Izumi
Jan 1, 1982·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H Hammer
Oct 1, 1983·Irish Journal of Medical Science·M Kiernan, B Bresnihan
Jan 1, 1981·Pharmacology & Therapeutics·P R Bergstresser, J N Gilliam
Sep 1, 1990·Journal of Reproductive Immunology·J A CastillaE García-Olivares
Jun 1, 1981·Veterinary Immunology and Immunopathology·G A SplitterW R Usinger
Nov 1, 1982·Veterinary Immunology and Immunopathology·O BartaP P Oyekan
Jul 1, 1983·Veterinary Immunology and Immunopathology·P J FelsbergP F Jezyk
May 1, 1992·Veterinary Immunology and Immunopathology·J S Nimmo WilkieP J Pascoe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.