PMID: 8941975Sep 1, 1996Paper

Suppressor macrophages mediate depressed lymphoproliferation in chickens infected with avian reovirus

Veterinary Immunology and Immunopathology
T PertileJ M Sharma

Abstract

A previous study indicated that spleens from reovirus-infected chickens contained macrophages that were primed to produce nitric oxide (NO). The presence of these primed macrophages correlated with depressed in vitro T cell mitogenesis. The current studies indicated that splenic adherent macrophages from virus-exposed chickens inhibited concanavalin A (ConA) induced proliferation of normal spleen cells. ConA-stimulated spleen cells from uninfected chickens, but not virus-exposed chickens, produced large quantities of interleukin-2 (IL-2) and a factor that induced NO production. This factor was tentatively named NO inducing factor (NOIF). The removal of macrophages from the spleens of virus-exposed chickens by plastic adherence resulted in partial recovery of ConA-induced proliferation and the production of normal levels of IL-2 and increased levels of NOIF, although these remained below normal. However, nonadherent spleen cells produced substantial quantities of NO, which indicated an incomplete removal of macrophages. Because removal by plastic adherence did not result in the depletion of all macrophages, spleen cells were panned with anti-CD3 antibody to obtain an almost pure population of T cells. Fractionated T cells from v...Continue Reading

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Citations

Mar 16, 2000·Developmental and Comparative Immunology·K A Schat, Z Xing
Apr 13, 2000·Veterinary Immunology and Immunopathology·I J Kim, J M Sharma
Mar 10, 2000·International Journal of Immunopharmacology·A Djeraba, P Quere
Jul 11, 2007·Avian Pathology : Journal of the W.V.P.A·Judith M A van den BrandGerry M Dorrestein
Jul 5, 2006·Viral Immunology·J M PalmquistJ M Sharma
Jul 9, 2014·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Sabina DarkeManfred Reinacher
Nov 4, 2004·BMC Cell Biology·Edward L OrganDonald H Rubin
Apr 2, 2002·Avian Diseases·Parag CharyJagdev M Sharma
Oct 31, 2019·International Reviews of Immunology·Aamir NawabMei Xiao
May 27, 2014·Expert Review of Vaccines·Shishir Kumar GuptaMadhan Mohan Chellappa

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