Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Lisa Nowoslawski AkhtarEtty N Benveniste

Abstract

HIV-1 replication within macrophages of the CNS often results in cognitive and motor impairment, which is known as HIV-associated dementia (HAD) in its most severe form. IFN-beta suppresses viral replication within these cells during early CNS infection, but the effect is transient. HIV-1 eventually overcomes this protective innate immune response to resume replication through an unknown mechanism, initiating the progression toward HAD. In this article, we show that Suppressor of Cytokine Signaling (SOCS)3, a molecular inhibitor of IFN signaling, may allow HIV-1 to evade innate immunity within the CNS. We found that SOCS3 is elevated in an in vivo SIV/macaque model of HAD and that the pattern of expression correlates with recurrence of viral replication and onset of CNS disease. In vitro, the HIV-1 regulatory protein transactivator of transcription induces SOCS3 in human and murine macrophages in a NF-kappaB-dependent manner. SOCS3 expression attenuates the response of macrophages to IFN-beta at proximal levels of pathway activation and downstream antiviral gene expression and consequently overcomes the inhibitory effect of IFN-beta on HIV-1 replication. These studies indicate that SOCS3 expression, induced by stimuli present i...Continue Reading

References

Feb 1, 1990·Clinical Immunology and Immunopathology·R S KornbluthD D Richman
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·K ConantE O Major
Aug 26, 1998·European Journal of Immunology·V T NguyenE N Benveniste
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J D WeissmanD S Singer
Oct 6, 1998·Annual Review of Biochemistry·G R StarkR D Schreiber
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·A AlbiniD M Noonan
Apr 25, 2000·Biochemical and Biophysical Research Communications·S GhezziA Albini
Jul 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M CotaG Poli
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D StoiberT Decker
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y DongE N Benveniste
May 20, 2003·Nature Immunology·Ben A CrokerWarren S Alexander
May 31, 2003·Nature Reviews. Immunology·Diane E Griffin
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Byung Oh KimJohnny J He
Jan 27, 2004·The Journal of Biological Chemistry·Luana GattoFlavia Bazzoni
Feb 27, 2004·European Journal of Clinical Investigation·M C D G HuigenH S L M Nottet
Jan 5, 2005·Nature Reviews. Immunology·Francisco González-Scarano, Julio Martín-García
Aug 20, 2005·Lancet Neurology·Justin C McArthurAvi Nath

❮ Previous
Next ❯

Citations

Dec 15, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Loyda M MeléndezDianedis Toro-Nieves
Nov 19, 2010·Journal of Virology·Lisa Nowoslawski Akhtar, Etty N Benveniste
Jun 14, 2013·Clinical & Developmental Immunology·Sandra L Bixler, Joseph J Mattapallil
May 7, 2015·Scientific Reports·Gopinath Krishnan, Nivedita Chatterjee
Apr 21, 2017·Scientific Reports·Victoria E ThaneyMarcus Kaul
Apr 22, 2011·Nature Reviews. Immunology·Dorian B McGavern, Silvia S Kang
May 2, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chun-Feng YuNatalija Novak
May 6, 2015·Molecular and Cellular Biology·Dong LiuWenlin Huang
Sep 28, 2018·Viral Immunology·Victoria E Thaney, Marcus Kaul
Apr 3, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kamakshi Prudhula DevalrajuVijaya Lakshmi Valluri
Aug 23, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Michael Bright YakassOsbourne Quaye
Dec 15, 2012·Pharmacological Reports : PR·Krzysztof LabuzekBogusław Okopień
Feb 26, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Martin HersbergerUNKNOWN Swiss HIV Cohort Study
Feb 22, 2011·European Journal of Immunology·Regina C MillerRoberto F Speck
Jul 8, 2011·Current Opinion in HIV and AIDS·Viviana Cobos-JiménezNeeltje A Kootstra
May 4, 2016·Cellular and Molecular Life Sciences : CMLS·R MahonyN J Stevenson
Jun 6, 2018·Frontiers in Cellular and Infection Microbiology·Dayakar AltiSuresh K Kalangi
Nov 21, 2018·Nature Microbiology·Seiki FujiwaraYumiko Imai
Apr 30, 2019·Frontiers in Immunology·Christine I Alston, Richard D Dix
Aug 29, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hongwei QinEtty N Benveniste
Dec 12, 2018·Frontiers in Immunology·Radheshyam MauryaHira L Nakhasi
Mar 8, 2019·Veterinary Research·Min FengXiquan Zhang
Sep 5, 2019·Frontiers in Immunology·Khalid RashidThomas Langmann
Mar 15, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Renata Sesti-CostaMarco Colonna
Feb 16, 2019·Frontiers in Microbiology·Vikas SoodAkhil C Banerjea
Feb 7, 2013·Molecular Cancer Research : MCR·Braden C McFarlandEtty N Benveniste
Jan 9, 2021·International Immunopharmacology·Parisa Shiri AghbashHossein Bannazadeh Baghi
Feb 12, 2021·Journal of Virology·Teslin S SandstromJonathan B Angel
May 1, 2021·Developmental and Comparative Immunology·Carolina SalazarSergio H Marshall
Jul 13, 2021·Frontiers in Immunology·Klara KleinVeronika Sexl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Justyna M DudaronekJanice E Clements
The Journal of Immunology : Official Journal of the American Association of Immunologists
Anja StirnweissAndrea Kröger
© 2021 Meta ULC. All rights reserved