PMID: 7546844Aug 1, 1995Paper

Suppressor of hairless, the Drosophila homologue of RBP-J kappa, transactivates the neurogenic gene E(spl)m8

Idengaku zasshi
T FurukawaT Honjo

Abstract

Suppressor of Hairless[Su(H)], the Drosophila homologue of RBP-J kappa is a novel type of sequence-specific DNA binding protein without known motifs, and highly conserved in various organisms. Su(H) regulates peripheral nervous system (PNS) development. Recently Su(H) was suggested to participate in the Notch-mediated signal transduction pathway. We show here that the Su(H) protein binds to TGTGGGAA sequence located 616 base-pairs upstream of the transcription initiation site of the Enhancer of split [E(spl)]m8 gene which is mapped to the terminus of the genetic cascade of the neurogenic genes. Su(H) transactivates the E(spl)m8 promoter not only in cultured Drosophila cells but also in vivo. The present study bridges the biochemical gap between Notch and E(spl) in the neurogenic gene cascade including Delta, Notch, deltex, Su(H), Hairless and E(spl).

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Citations

May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·E C Lai, G M Rubin
Jul 14, 2005·BMC Neuroscience·Michael Y ChaoAnne C Hart
Feb 15, 2012·Journal of Cell Science·Elena Domanitskaya, Trudi Schüpbach
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Jun 1, 2004·Development·Stefan HansJosé A Campos-Ortega

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