PMID: 4886537Apr 21, 1967Paper

Suppressor selectrion for amino acid replacements expected on the basis of the genetic code

Science
H Berger, C Yanofsky

Abstract

In studies with A protein mutants of the tryptophan synthetase of Escherichia coli, missense supressors have been used to select for codon changes and corresponding amino acid replacements that are normally unobservable. The technique has permitted the detection of additional amino acid replacements expected on the basis of the genetic code.

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