Supracellular Actomyosin Mediates Cell-Cell Communication and Shapes Collective Migratory Morphology

IScience
Heng WangJiong Chen

Abstract

During collective cell migration, front cells tend to extend a predominant leading protrusion, which is rarely present in cells at the side or rear positions. Using Drosophila border cells (BCs) as a model system of collective migration, we revealed the presence of a supracellular actomyosin network at the peripheral surface of BC clusters. We demonstrated that the Myosin II-mediated mechanical tension as exerted by this peripheral supracellular network not only mediated cell-cell communication between leading BC and non-leading BCs but also restrained formation of prominent protrusions at non-leading BCs. Further analysis revealed that a cytoplasmic dendritic actin network that depends on the function of Arp2/3 complex interacted with the actomyosin network. Together, our data suggest that the outward pushing or protrusive force as generated from Arp2/3-dependent actin polymerization and the inward restraining force as produced from the supracellular actomyosin network together determine the collective and polarized morphology of migratory BCs.

Citations

Nov 12, 2020·American Journal of Physiology. Cell Physiology·Eleana ParajónDouglas N Robinson
Sep 5, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Maik C Bischoff, Sven Bogdan

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Methods Mentioned

BETA
confocal microscopy
GTPase
FRET

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