PMID: 9181434Jun 1, 1997Paper

Suprachiasmatic nuclei lesions do not eliminate homeostatic thermoregulatory responses in rats

Journal of Biological Rhythms
M WachulecE Satinoff

Abstract

Electrolytic lesions aimed at the suprachiasmatic nuclei (SCN) were made in male Long-Evans rats. Body temperature (Tb), activity, and drinking were monitored continuously in a 12-h light:12-h dark (12:12 LD) cycle at an ambient temperature of 23 degrees C. Large SCN lesions eliminated activity and drinking rhythms and abolished or reduced the circadian rhythm of Tb. The Tb responses of the rats were measured in L after exposure to cold and injection of lipopolysaccharide (LPS), a fever-producing drug, and in both L and D during a 30-min exposure to a novel cage. Rats with SCN lesions (SCNX) maintained their Tb as well as did controls during 2-h exposure to 2 degrees C. They also showed the expected increases in Tb in response to novelty and LPS. Nevertheless, there were differences between SCNX rats and other rats. When measured 9 h after LPS injection, SCNX rats had lower Tb in D than did sham-lesioned or intact rats or rats with lesions that missed the SCN. This is not surprising; the Tb of SCNX rats does not go as high as that of intact rats in D. However, it was surprising that at night SCNX rats increased their Tb in response to novelty (lights on in the test situation), whereas normal rats did not. For some reason, light...Continue Reading

References

Jul 1, 1979·Physiological Reviews·B Rusak, I Zucker
Nov 1, 1976·Brain Research Bulletin·E SatinoffP Teitelbaum
Jun 1, 1991·Physiology & Behavior·E Briese, M Cabanac
Jan 1, 1990·Experimental Gerontology·R RefinettiE Satinoff
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Citations

Mar 11, 1998·Clinical and Experimental Pharmacology & Physiology·E Satinoff
Jun 15, 2011·Molecular and Cellular Endocrinology·I SchmutzJ A Ripperger
Jun 27, 2008·Experimental Gerontology·Erin M GibsonLance J Kriegsfeld
Jul 22, 2009·Ageing Research Reviews·Dietmar Weinert
Jul 28, 2004·Physiology & Behavior·Sean W CainMartin R Ralph
May 11, 2002·Journal of Biological Rhythms·Elizabeth PelosoEvelyn Satinoff
Apr 30, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F C BakerD McGinty
May 15, 2018·Frontiers in Endocrinology·Frederico Sander Mansur MachadoAndries Kalsbeek

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