Suprachiasmatic Nucleus and Subparaventricular Zone Lesions Disrupt Circadian Rhythmicity but Not Light-Induced Masking Behavior in Nile Grass Rats

Journal of Biological Rhythms
Andrew J GallL Smale

Abstract

The ventral subparaventricular zone (vSPVZ) receives direct retinal input and influences the daily patterning of activity in rodents, making it a likely candidate for the mediation of acute behavioral responses to light (i.e., masking). We performed chemical lesions aimed at the vSPVZ of diurnal grass rats (Arvicanthis niloticus) using N-methyl-D,L-aspartic acid (NMA), a glutamate agonist. Following NMA lesions, we placed grass rats in various lighting conditions (e.g., 12:12 light-dark, constant dark, constant light); presented a series of light pulses at circadian times (CT) 6, 14, 18, and 22; and placed them in a 7-h ultradian cycle to assess behavioral masking. Extensive bilateral lesions of the vSPVZ disrupted the expression of circadian rhythms of activity and abolished the circadian modulation of masking responses to light, without affecting light-induced masking behavior per se. We also found that in diurnal grass rats, NMA was capable of destroying not only neurons of the vSPVZ but also those of the suprachiasmatic nucleus (SCN), even though excitotoxins have been ineffective at destroying cells within the SCN of nocturnal rodents. The vulnerability of the grass rat's SCN to NMA toxicity raises the possibility of a dif...Continue Reading

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Citations

Sep 23, 2016·Drug Development Research·Carmel BiluNoga Kronfeld-Schor
Oct 1, 2018·The European Journal of Neuroscience·Lily YanAntonio A Nunez
Nov 4, 2017·Frontiers in Neurology·Santiago A PlanoJuan J Chiesa
May 5, 2018·Laboratory Animals·Roberto Refinetti, G J Kenagy
May 27, 2017·ELife·Shanaz DiesslerPaul Franken
May 6, 2021·Npj Aging and Mechanisms of Disease·Dorela D Shuboni-MulliganDeeDee K Smart

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