Suprachiasmatic Nucleus-Arcuate Nucleus Axis: Interaction Between Time and Metabolism Essential for Health.

Obesity
Rebeca Méndez-HernándezRuud M Buijs

Abstract

In mammals, time and metabolism are tightly coupled variables; this relationship can be illustrated by numerous examples, such as the circadian variation in food intake or the circadian response to a glucose bolus. We review evidence that the interaction between the suprachiasmatic nucleus and the arcuate nucleus plays a key role in the execution of these functions. The nuclei are reciprocally connected via different projections, and this interaction provides an ideal anatomical framework to modify the temporal output of the hypothalamus to metabolic organs as a consequence of the feedback from the periphery. The suprachiasmatic nucleus-arcuate nucleus relationship is essential to integrate metabolic information into the circadian system and thus adapt circadian rhythms in core body temperature, locomotor activity, food intake, and circulating molecules such as glucose and corticosterone. With the rise in obesity-associated diseases in the world population, gaining knowledge about this relationship, and the consequences of disturbing this liaison, is essential to understand the pathogenesis of obesity.

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S T Inouye, H Kawamura
Mar 1, 1975·The Journal of Comparative Neurology·L W Swanson, W M Cowan
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B G Stanley, S F Leibowitz
Jan 1, 1981·Neuroscience·F K StephanR L Moss
Aug 1, 1994·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·R RefinettiM Menaker
Aug 6, 1999·Frontiers in Neuroendocrinology·Y IbataF Amaya
Jun 10, 2000·Journal of Neuroendocrinology·K Saeb-ParsyR E Dyball
Sep 3, 2002·Neuroscience and Biobehavioral Reviews·Jan H Strubbe, Gertjan van Dijk
Nov 26, 2003·Journal of Neuroendocrinology·A KalsbeekR M Buijs
Mar 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ehab Tousson, Hilmar Meissl
Sep 3, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andries KalsbeekRuud M Buijs
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Naoki UyamaHendrik Reynaert
Apr 9, 2005·Methods in Enzymology·Rae Silver, William J Schwartz
Nov 17, 2006·Journal of Biological Rhythms·A KalsbeekR M Buijs
Nov 7, 2007·Cell Metabolism·Akira KohsakaJoseph Bass
Mar 5, 2008·Cell Metabolism·Andrea MesarosJens C Brüning
Sep 23, 2009·The Journal of Physiology·Bengt F BelgardtJens C Brüning
Jul 29, 2010·Physiological Reviews·Diego A Golombek, Ruth E Rosenstein
Sep 2, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M F WiaterS Ritter
Sep 3, 2011·Nature Reviews. Neuroscience·Christopher S Colwell
Apr 12, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ai-Jun LiSue Ritter
May 18, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hadas ShermanOren Froy

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Citations

Dec 22, 2020·Chronobiology International·Swetha Gopalakrishnan, Nisha N Kannan

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