Suprachiasmatic nucleus in a patient with multiple system atrophy with abnormal circadian rhythm of arginine-vasopressin secretion into plasma

Journal of the Neurological Sciences
T OzawaS Tsuji

Abstract

We performed a quantitative investigation of arginine-vasopressin (AVP) immunopositive neurons in the suprachiasmatic nucleus (SCN), which is the endogenous clock of the brain of a patient with multiple system atrophy (MSA) who exhibited nocturnal polyuria associated with decreased urinary specific gravity and depression of nocturnal AVP secretion. Eleven age- and sex-matched subjects were used as controls. Although, the number of AVP-positive neurons was decreased in neither the supraoptic nucleus nor the paraventricular nucleus, the number of AVP-positive neurons in the SCN was decreased and gliosis was present in the SCN. The cytoplasmic area of AVP-immunopositive neurons in the SCN was smaller in the patient than in the control subjects. These findings raise the possibility that SCN is involved in MSA and the neurodegeneration in the SCN results in altered circadian rhythm of AVP secretion and nocturnal polyuria.

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Citations

Nov 17, 2001·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·T OzawaS Tsuji
Nov 8, 2006·Acta Neuropathologica·Eduardo E BenarrochJoseph E Parisi
Sep 23, 2003·Current Urology Reports·Jeffrey P Weiss, Jerry G Blaivas
Aug 16, 2008·Current Urology Reports·Jeffrey P WeissJerry G Blaivas
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Jul 17, 2013·Drugs·Christoph SchroederHoracio Kaufmann
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May 2, 2003·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Kiyomitsu Oyanagi
Nov 21, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Mari Yoshida
Jul 1, 2006·Women's Health·Jeffrey P Weiss, Jerry G Blaivas
Mar 2, 2011·BJU International·Dev Mohan GulurMarcus J Drake
Feb 12, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Osamu NatsumeYoshihiko Hirao
Jun 24, 2014·Movement Disorders Clinical Practice·Sabra M Abbott, Aleksandar Videnovic
Oct 9, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E VichayanratC J Mathias
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Sep 15, 2021·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Yusuke SakataOsamu Onodera

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