PMID: 8590270Jan 1, 1995Paper

Suprachiasmatic nucleus in the neural circuitry for the circadian elevation of intraocular pressure in rabbits

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
J H Liu, B E Shieh

Abstract

Intraocular pressure (IOP) in light-dark entrained rabbits changes in a circadian pattern. Previous studies indicate that signals for the circadian IOP elevation in the early dark phase come from the central nervous system (CNS) via the ocular sympathetic nerves. Its neural circuitry in the CNS was totally unclear. In the present study, the role of the suprachiasmatic nucleus in the circuitry was investigated. Adult New Zealand albino rabbits were entrained in a daily 12 hr/12 hr light-dark cycle, and their circadian IOP elevations around the onset of dark were determined. Bilateral lesions of the suprachiasmatic nuclei were made by heat probe and verified by histology. Change in the circadian IOP elevation was monitored for up to 3 months. After the lesion, there was a significant reduction of the circadian IOP elevation for 2 weeks. Elevations in the plasma concentration of melatonin and the aqueous humor concentration of norepinephrine (NE) in the early dark phase were significantly reduced. When exposed to constant light, the residual circadian IOP elevation in the postoperative rabbits was further reduced to the level seen in intact rabbits exposed to constant light. In postoperative weeks 6-10, the circadian IOP elevation...Continue Reading

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Citations

Nov 12, 2003·Experimental Eye Research·Makoto AiharaRobert N Weinreb
Mar 5, 2008·Progress in Retinal and Eye Research·Allan F Wiechmann, Jody A Summers
Apr 4, 2017·Korean Journal of Ophthalmology : KJO·Yeoun Sook ChunJoon Mo Kim
Nov 28, 2018·Investigative Ophthalmology & Visual Science·Shunsuke TsuchiyaRussell N Van Gelder
Nov 9, 2018·The European Journal of Neuroscience·Raúl Aguilar-Roblero, Gabriela González-Mariscal
Sep 10, 2019·Chronobiology International·Natalia ZiółkowskaBogdan Lewczuk
Nov 27, 2019·The Journal of Physiology·Kayla R Ficarrotta, Christopher L Passaglia
Jul 20, 2001·Current Eye Research·E L GondimR N Weinreb

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