Supraclavicular Brown adipose tissue FDG uptake and cardiovascular disease

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Richard A P TakxAhmed Tawakol

Abstract

Pre-clinical data suggests a negative correlation between brown adipose tissue (BAT) and the degree of coronary atherosclerosis. We sought to evaluate the relationship between (18)F-FDG uptake in supraclavicular BAT in relation to: 1) arterial inflammation and 2) subsequent cardiovascular disease (CVD) events in humans. Individuals who underwent (18)F-FDG PET/CT for clinical indications, but who did not have either cancer or known atherosclerotic disease at time of imaging were included. While blinded to clinical data, (18)F-FDG uptake was measured within BAT (in supraclavicular region) as well as in subcutaneous adipose tissues (SAT). Tissue density was evaluated using CT (Hounsfield units). Arterial inflammation was assessed by measuring of arterial FDG uptake and calculating target to background ratio (TBR). Cardiovascular disease (CVD) events were independently adjudicated by blinded cardiologists. Thereafter, the relationship between BAT activity and CVD events was evaluated. A total of 443 patients (age, 43% male, body mass index (BMI) 26 (23-31)) were included and 34 experienced a cardiovascular event during a median follow-up of 4 years. BAT activity negatively correlated with arterial inflammation (r=-0.178, p<0.01), a...Continue Reading

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