Supracolloidal Assemblies as Sacrificial Templates for Porous Silk-Based Biomaterials

International Journal of Molecular Sciences
John G HardyChristine E Schmidt

Abstract

Tissues in the body are hierarchically structured composite materials with tissue-specific properties. Urea self-assembles via hydrogen bonding interactions into crystalline supracolloidal assemblies that can be used to impart macroscopic pores to polymer-based tissue scaffolds. In this communication, we explain the solvent interactions governing the solubility of urea and thereby the scope of compatible polymers. We also highlight the role of solvent interactions on the morphology of the resulting supracolloidal crystals. We elucidate the role of polymer-urea interactions on the morphology of the pores in the resulting biomaterials. Finally, we demonstrate that it is possible to use our urea templating methodology to prepare Bombyx mori silk protein-based biomaterials with pores that human dermal fibroblasts respond to by aligning with the long axis of the pores. This methodology has potential for application in a variety of different tissue engineering niches in which cell alignment is observed, including skin, bone, muscle and nerve.

References

Dec 1, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Andrew R Hirst, David K Smith
Jul 18, 2006·Current Opinion in Structural Biology·Luc Jaeger, Arkadiusz Chworos
Sep 26, 2008·Chemical Communications : Chem Comm·Jamie R MoffatDavid K Smith
Sep 27, 2008·Science·Faisal A AldayeHanadi F Sleiman
Jul 21, 2009·Biochemical Society Transactions·John G Hardy, Thomas R Scheibel
Sep 5, 2009·Annual Review of Entomology·Tara D SutherlandDavid J Merritt
Feb 20, 2010·Acta Biomaterialia·Scott A Zawko, Christine E Schmidt
Sep 28, 2010·Current Opinion in Chemical Biology·Pik Kwan LoHanadi F Sleiman
Oct 1, 2011·Nature Protocols·Danielle N RockwoodDavid L Kaplan
Oct 21, 2011·Chemical Society Reviews·Christopher K McLaughlinHanadi F Sleiman
Mar 13, 2012·Chemistry : a European Journal·Eugen Stulz
Jun 19, 2012·Current Opinion in Biotechnology·Faramarz EdalatAli Khademhosseini
Nov 10, 2012·Advanced Drug Delivery Reviews·Banani KunduXungai Wang
Nov 28, 2012·Advanced Healthcare Materials·Jeffrey J RiceJeffrey A Hubbell
Mar 19, 2013·Methods in Molecular Biology·Rucsanda C PredaDavid L Kaplan
Mar 20, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Karina M M CarneiroHanadi F Sleiman
Jan 28, 2014·Advanced Healthcare Materials·Catarina A CustódioJoão F Mano
Mar 25, 2014·Current Opinion in Biotechnology·Kristin Schacht, Thomas Scheibel
Jun 2, 2014·The Journal of Chemical Physics·William M JacobsDaan Frenkel
Nov 13, 2014·Scientific Reports·Ruohai GuoLi-Tang Yan
May 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·William M JacobsDaan Frenkel

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Methods Mentioned

BETA
Fluorescence

Software Mentioned

Olympus cellSens

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