Supragingival mycobiome and inter-kingdom interactions in dental caries.

Journal of Oral Microbiology
Divyashri BaraniyaNezar Noor Al-Hebshi

Abstract

Background: Recent studies have reveled the presence of a complex fungal community (mycobiome) in the oral cavity. However, the role of oral mycobiome in dental caries and its interaction with caries-associated bacteria is not yet clear. Methods: Whole-mouth supragingival plaque samples from 30 children (6-10 years old) with no caries, early caries, or advanced caries were sequenced for internal transcribed spacer 2 (ITS-2). The mycobiome profiles were correlated with previously published bacteriome counterparts. Interaction among selected fungal and bacterial species was assessed by co-culture or spent media experiments. Results: Fungal load was extremely low. Candida, Malassezia, Cryptococcus, and Trichoderma spp. were the most prevalent/abundant taxa. Advanced caries was associated with significantly higher fungal load and prevalence/abundance of Candida albicans. Cryptococcus neoformans and Candida sake were significantly over-abundant in early caries, while Malassezia globosa was significantly enriched in caries-free subjects. C. albicans correlated with Streptococcus mutans and Scardovia wiggsiae among other caries-associated bacteria, while M. globosa inversely correlated with caries-associated bacteria. In-vitro, M. glo...Continue Reading

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Citations

Sep 15, 2020·Journal of Dental Research·P I Diaz, A Dongari-Bagtzoglou
Jul 13, 2021·Frontiers in Microbiology·Vivianne Cruz de JesusPrashen Chelikani
Sep 1, 2021·Periodontology 2000·Cristina Cunha Villar, Anna Dongari-Bagtzoglou

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Datasets Mentioned

BETA
PRJNA561125

Methods Mentioned

BETA
PCR

Software Mentioned

Quantitative Insights Into Microbial Ecology ( QIIME )
R Package
BLASTn
R
PEAR
mothur

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