PMID: 6404867Mar 1, 1983Paper

Supraglottic laryngeal carcinoma: an analysis of dose-time-volume factors in 410 patients

International Journal of Radiation Oncology, Biology, Physics
A R HarwoodT Elhakim

Abstract

Four hundred and ten patients with supraglottic laryngeal carcinoma treated with moderate dose radical radiotherapy with surgery for salvage (RRSS) were analyzed in detail to determine optimal dose-time-volume parameters to be used in the treatment of each stage of supraglottic carcinoma. In the RRSS group 41% are alive and well at 5 years, 38% died of their tumor and 21% of intercurrent disease. Presence or absence of nodal disease has a major impact on survival. Local control is approximately 70% in T1, T2N0 patients and approximately 50% in T3 and T4N0 patients. Seventeen percent of T1 and T2N0 patients failed in the initially negative neck. Ten major complications (2.4%) have been seen. Local control by irradiation was not influenced by dose or field size. Regional control in the initially negative neck was markedly increased with the use of larger irradiation field sizes. Field sizes of less than 7 X 7 cm resulted in an 18% neck failure rate as compared to 3% with larger field sizes (p = 0.00005). This particularly applied to early stage disease. As a result of the use of larger irradiation field sizes giving reduced neck failure rates, improvement in survival has been seen in early stage supraglottic patients. The results...Continue Reading

References

Jan 1, 1979·Acta Radiologica: Oncology, Radiation, Physics, Biology·M Hjelm-HansenC Lund
Jun 1, 1975·The Laryngoscope·J R Cunningham, J V Van Dyk
Jan 1, 1970·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·L J Shukovsky

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Citations

Oct 1, 1996·Journal of Surgical Oncology·P C O'Brien
Jul 1, 1997·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·M F VegaS F Vega
Aug 1, 1988·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G H Fletcher
Jun 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J CarlO Greisen
Jul 15, 1996·International Journal of Radiation Oncology, Biology, Physics·F F YinD F Nelson
Sep 16, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Leo PfreundnerMichael Flentje
May 4, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R SuwinskiH R Withers
Apr 4, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J L Lefebvre
Sep 1, 1997·American Journal of Otolaryngology·G SprianoM Tordiglione
Mar 5, 1998·International Journal of Radiation Oncology, Biology, Physics·J T ParsonsN J Cassisi
Mar 22, 2000·International Journal of Radiation Oncology, Biology, Physics·A J SykesA E Brewster
Nov 7, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R L BhalavatU Mahantshetty
Jul 5, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·A Mucha-Małecka, K Składowski
Mar 15, 2016·International Journal of Radiation Oncology, Biology, Physics·Sven van den BoschJohannes H A M Kaanders
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·H D ThamesW A Brock
Feb 1, 1987·International Journal of Radiation Oncology, Biology, Physics·J W DenhamN D Harvey
Jan 1, 1990·International Journal of Radiation Oncology, Biology, Physics·A R Harwood
May 1, 1987·International Journal of Radiation Oncology, Biology, Physics·P GarrettM Singer
Feb 1, 1988·International Journal of Radiation Oncology, Biology, Physics·W M MendenhallR R Million
Mar 1, 1986·International Journal of Radiation Oncology, Biology, Physics·D A Morgan
Nov 1, 1985·International Journal of Radiation Oncology, Biology, Physics·T J WallL Milas
Jun 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J Bernier, J P Bataini
Apr 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G K ZagarsL J Peters
Jan 5, 1999·Seminars in Radiation Oncology·A A Forastiere
Sep 24, 1999·Hematology/oncology Clinics of North America·M L Gillison, A A Forastiere
Mar 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B M Dubray, H D Thames
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arlene A ForastiereAndy Trotti
Aug 12, 2005·The Laryngoscope·Donald G SessionsGershon J Spector
Sep 12, 1998·Otolaryngologic Clinics of North America·D Shasha, L B Harrison
Aug 5, 2006·International Journal of Radiation Oncology, Biology, Physics·Sue S YomAdam S Garden
Feb 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W L van PuttenP C Levendag
Feb 28, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B ScolaC Ramirez
Jul 29, 2004·The Laryngoscope·Gershon J SpectorBruce H Haughey
Jul 20, 2007·Head & Neck·Gabriela BuckSandro J Stoeckli
May 1, 2010·Expert Opinion on Pharmacotherapy·Missak HaigentzAlfio Ferlito
Dec 5, 1991·The New England Journal of Medicine
Jun 13, 1991·The New England Journal of Medicine·UNKNOWN Department of Veterans Affairs Laryngeal Cancer Study GroupWilliam G Henderson
Jun 1, 1984·International Journal of Radiation Oncology, Biology, Physics·G H Fletcher

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