Supramammillary neural discharge patterns and hippocampal EEG

Brain Research Bulletin
I J Kirk

Abstract

Rhythmic multiunit activity, leading the negative peak of concurrently recorded dentate rhythmical slow-wave activity (RSA, theta) by a constant degree over a range of RSA frequencies, was observed in the supramammillary nucleus (SuM) after carbachol infusion (5%, 0.25-0.5 microliter) into the nucleus pontis oralis (RPO). As the rhythmic SuM activity survived bilateral transection anterior to SuM, its occurrence is not dependent on descending influences from the septum or hippocampus. Infusion of additional carbachol into the RPO resulted in epileptiform "sharp-waves" in the hippocampal EEG, and correlated nonrhythmic cell discharge in the SuM. Bilateral transection rostral to SuM abolished the sharp-wave related SuM activity (and restored SuM rhythmical activity). Thus, in contrast to RSA related rhythmical SuM discharge, sharp-wave related SuM discharge seems dependent on descending projections from the hippocampus.

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Citations

Mar 7, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·G A Burns, M P Young
Jul 20, 2012·Physiological Reviews·Ritchie E BrownRobert W McCarley
Jun 25, 2009·Progress in Neurobiology·Calvin K Young, Jos J Eggermont
Sep 1, 2010·Wiley Interdisciplinary Reviews. Cognitive Science·Ian J KirkTimothy J Teyler
Dec 9, 2010·The European Journal of Neuroscience·Shawn S WinterDouglas G Wallace
Jul 17, 2016·The European Journal of Neuroscience·Renata BocianTomasz Kowalczyk
Mar 26, 2021·Neuronal Signaling·Aimée Freeburn, Robert Gordon Keith Munn

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