Supramolecular catalysis of Strecker reaction in water under neutral conditions in the presence of beta-cyclodextrin

The Journal of Organic Chemistry
K SurendraK Rama Rao

Abstract

An environmentally benign and highly efficient procedure for the nucleophilic addition of trimethylsilyl cyanide to imines (Strecker reaction) has been developed under biomimetic conditions in water in the presence of beta-cyclodextrin to afford alpha-aminonitriles in quantitative yields. The use of cyclodextrin precludes the use of either acid or base, and the catalyst can be recycled a number of times without loss in activity.

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Citations

Mar 7, 2009·The Journal of Organic Chemistry·Jamie JarusiewiczKyung Woon Jung
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·G K Surya PrakashGeorge A Olah
Nov 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jeyakannu PalanirajaMariadhas Valan Arasu
Aug 18, 2017·Chemistry : a European Journal·Bijan RoyPartha Sarathi Mukherjee
Sep 14, 2012·Chemical Society Reviews·Zeyuan DongJunqiu Liu
Jul 25, 2020·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Caroline GrundkeTill Opatz
Jan 24, 2008·The Journal of Organic Chemistry·V Pavan KumarK Rama Rao
Mar 7, 2014·The Journal of Organic Chemistry·Kai YangJin-Tao Liu
Jul 17, 2007·The Journal of Organic Chemistry·José Luis García RuanoInés Alonso

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