Supramolecular control of hetero-multinuclear polytopic binding of metal ions (Zn(II), Cu(I)) at a single calix[6]arene-based scaffold

Inorganic Chemistry
Jean-Noël RebillyOlivia Reinaud

Abstract

A Calix[6]arene scaffold was functionalized to provide a tridentate binding site at the small rim and three bidentate chelate sites at the large rim of the cone to generate a heteropolytopic ligand. Its complexation to one equivalent of Zn(II) at the small rim yields a funnel complex displaying both host-guest properties and preorganization of the three chelate groups at the large rim. These two aspects allowed the full control of the binding events to regioselectively form dinuclear Zn(II) and heteropolynuclear Zn(II)/Cu(I) complexes. The heteropolynuclear systems all rely on the host-guest relationship thanks to the induced-fit behavior of the calix cavity. With the short guest MeCN, the large rim is preorganized into a trigonal tris-triazole core and accommodates a single Cu(I) ion. A long guest breaks this spatial arrangement, and three Cu(I) ions can then be bound at the tris-bidentate triazole-dimethylamine site at the large rim. In a noncoordinating solvent however, the tetranuclear complex is submitted to scrambling and the addition of exogenous π-acceptor ligands is required to control the binding of Cu(I) in a well-defined environment. Hindrance selectivity was then induced by the accessibility at the small rim site. ...Continue Reading

References

Dec 29, 2000·Chemistry : a European Journal·Y RondelezO Reinaud
Feb 19, 2002·Chemical Reviews·Claude PiguetGérard Hopfgartner
Aug 5, 1997·Chemical Reviews·M. Morgan Conn, Julius Rebek
Aug 5, 1997·Chemical Reviews·Brian Linton, Andrew D. Hamilton
Feb 12, 2004·Chemical Reviews·James P CollmanLei Fu
Jan 18, 2005·Chemical Communications : Chem Comm·Stefán JónssonKenneth Wärnmark
Jun 24, 2006·Angewandte Chemie·Heinz DeckerFelix Tuczek
Oct 31, 2006·Biochimica Et Biophysica Acta·Michal OtyepkaPavel Anzenbacher
Dec 6, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Sophie RomainMarie-Noëlle Collomb
Mar 26, 2008·Inorganic Chemistry·James P CollmanYing Yang
Oct 29, 2008·Chemical Communications : Chem Comm·James P Collman, Richard A Decréau
Jun 9, 2009·Organic & Biomolecular Chemistry·David CoquièreOlivia Reinaud
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Shigehisa Akine, Tatsuya Nabeshima
Mar 10, 2010·Journal of the American Chemical Society·Benoit ColassonOlivia Reinaud
Feb 18, 2011·Organic & Biomolecular Chemistry·Stéphane Le GacIvan Jabin
Aug 19, 2011·Chemical Reviews·Marina M Safont-SempereFrank Würthner

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Citations

Jul 4, 2013·Inorganic Chemistry·William B Tolman
Apr 4, 2017·Chemistry : a European Journal·Charlotte RémyOlivia Reinaud
Oct 17, 2014·Chemical Society Reviews·Jean-Noël RebillyOlivia Reinaud
May 14, 2014·Chemistry : a European Journal·Xiaoyan ZhangHaibing Li
Oct 2, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Poisson GuillaumeMarsura Alain
Oct 27, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Sarah RichardJean-Noël Rebilly

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