Supramolecular Dye Aggregate Assembly Enables Ratiometric Detection and Discrimination of Lysine and Arginine in Aqueous Solution

ACS Omega
Aafrin M Pettiwala, Prabhat K Singh

Abstract

Constructing sensor systems for rapid and selective detection of small biomolecules such as amino acids is a major area of focus in bioanalytical chemistry. Considering the biological relevance of arginine and lysine, significant efforts have been directed to develop fluorescent sensors for their detection. However, these developed sensors suffer from certain disadvantages such as poor aqueous solubility, technically demanding and time-consuming synthetic protocols, and more importantly, most of them operate through single wavelength measurements, making their performance prone to small variations in experimental conditions. Herein, we report a ratiometric sensor that operates through lysine- and arginine-induced dissociation of a supramolecular assembly consisting of emissive H-aggregates of a molecular rotor dye, thioflavin-T (ThT), on the surface of a polyanionic supramolecular host, sulfated β-cyclodextrin. This disassembly brings out the modulation of monomer-aggregate equilibrium in the system which acts as an ideal scheme for the ratiometric detection of lysine and arginine in the aqueous solution. Besides facile framework of our sensor system, it employs a commercially available inexpensive probe molecule, ThT, which pr...Continue Reading

References

Jan 1, 1975·Annual Review of Biochemistry·P Felig
Oct 2, 1992·Brain Research·A D'AnielloL Petrucelli
Oct 1, 1987·Biochemical Medicine and Metabolic Biology·C HirayamaS Kato
Mar 17, 2001·Chemistry & Biology·T Kodadek
May 8, 2002·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·H YoshidaM Yamaguchi
Dec 17, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroK D Tew
Aug 11, 2004·The Journal of Nutritional Biochemistry·Guoyao WuJ Marc Rhoads
Jan 27, 2005·Journal of the American Chemical Society·Yoshiaki SatoHideki Kandori
May 15, 2007·The Journal of Physical Chemistry. a·Vitali I StsiapuraIrina M Kuznetsova
Mar 21, 2009·Amino Acids·Guoyao Wu
Jan 26, 2010·The Journal of Physical Chemistry. B·Prabhat K SinghSukhendu Nath
Jan 30, 2010·Chemical Society Reviews·Yong Chen, Yu Liu
Apr 13, 2010·The Journal of Physical Chemistry. B·Prabhat K SinghSukhendu Nath
Sep 8, 2010·Chemical Society Reviews·Pavel AnzenbacherMaria E Kozelkova
Nov 11, 2010·Amino Acids·Najoua GuelzimDominique Hermier
Jan 14, 2011·Chemical Communications : Chem Comm·Ying ZhouJuyoung Yoon
Mar 30, 2011·Physical Chemistry Chemical Physics : PCCP·Prabhat K SinghSukhendu Nath
Jul 30, 2011·Chemical Society Reviews·Ying Zhou, Juyoung Yoon
Sep 9, 2011·Bioanalysis·Nadia Y Ashri, Mohamed Abdel-Rehim
Nov 2, 2011·Advances in Nutrition·Guoyao Wu
Jun 19, 2012·Chemical Reviews·Yuming YangFuyou Li
Oct 29, 2013·The Journal of Organic Chemistry·Ruixue PengXiaoming Feng
Nov 8, 2013·Chemical Communications : Chem Comm·Tsuyoshi MinamiPavel Anzenbacher
Oct 7, 2014·Chemical Society Reviews·Min Hee LeeJonathan L Sessler
Oct 18, 2014·ACS Applied Materials & Interfaces·Heng-Chia ChangJa-An Annie Ho
Feb 27, 2015·Chemical Reviews·Lei YouEric V Anslyn
Oct 16, 2015·Chemical Communications : Chem Comm·Hui WangS Thayumanavan
Mar 31, 2016·Chemistry : a European Journal·Niyati H Mudliar, Prabhat K Singh
Oct 28, 2016·Chemical Communications : Chem Comm·Qian WangYun-Bao Jiang

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Citations

Jul 5, 2019·Organic & Biomolecular Chemistry·Goutam ChakrabortyHaridas Pal
Jun 11, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Goutam ChakrabortyHaridas Pal
Apr 18, 2018·Chemical Communications : Chem Comm·Aafrin M Pettiwala, Prabhat K Singh
Nov 18, 2020·International Journal of Biological Macromolecules·Niyati H MudliarPrabhat K Singh
Feb 24, 2021·International Journal of Biological Macromolecules·Shrishti P PandeyPrabhat K Singh
Apr 17, 2021·Physical Chemistry Chemical Physics : PCCP·Akshat M DesaiPrabhat K Singh
Mar 25, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Ankur A AwasthiPrabhat K Singh
Apr 27, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Tianran WangNao Xiao
Jun 18, 2021·The Journal of Physical Chemistry. B·Gaurav SinghPrabhat K Singh
Jul 1, 2021·Physical Chemistry Chemical Physics : PCCP·Shrishti P PandeyPrabhat K Singh
Sep 27, 2018·Organic Letters·Frescilia Octa-SmolinJochen Niemeyer
Oct 15, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Gaurav Singh, Prabhat K Singh
Dec 7, 2018·Chemical Reviews·Teresa L MakoMindy Levine

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Methods Mentioned

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nuclear magnetic resonance
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