Supramolecular Encapsulation of a Neurotransmitter Serotonin by Cucurbit[7]uril

Frontiers in Chemistry
Falguni ChandraApurba L Koner

Abstract

pH-dependent host-guest complexation of a monoamine neurotransmitter, Serotonin, with cucurbit[7]uril has been thoroughly investigated. The binding phenomena were explored using steady-state and time-resolved fluorescence spectroscopy at different pH values. At lower pH, i.e., protonated Serotonin, the binding affinity with cucurbit[7]uril was significantly higher compared to higher pH. Furthermore, detailed NMR titration experiments depicted the solution structure of the host-guest complex through the complexation induced chemical shift values. A competitive binding assay with cesium ions at pD 2.8 was subsequently performed for the further manifestation of the binding. Finally, the molecular docking studies provided well-documented proof of the 1:1 inclusion complex and the geometry of the complex. We believe that understanding from such studies can be important for pH-controlled delivery of serotonin for biological applications.

References

May 1, 1995·Journal of Psychosomatic Research·S L Dubovsky, M Thomas
Oct 1, 1996·Biophysical Journal·A ChattopadhyayS Mukherjee
Apr 18, 1998·Biochimica Et Biophysica Acta·H Ouyang, H J Vogel
Jan 3, 2001·European Journal of Pharmacology·J Veenstra-VanderWeeleE H Cook
Jul 18, 2002·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·C RuibalM Aldegunde
Jan 4, 2003·Science·Diego J WaltherMichael Bader
Sep 24, 2004·IEEE Transactions on Nanobioscience·Cesar MarquezWerner M Nau
Jun 28, 2005·Nucleic Acids Research·Dina Schneidman-DuhovnyHaim J Wolfson
May 23, 2009·Organic & Biomolecular Chemistry·Ruibing WangJohn A Ripmeester
Jul 28, 2009·Annual Review of Medicine·Miles BergerBryan L Roth
Jan 12, 2010·Journal of the American Chemical Society·Sharmistha Dutta ChoudhuryAchikanath C Bhasikuttan
Feb 14, 2012·Advanced Drug Delivery Reviews·Indrajit Ghosh, Werner M Nau
Dec 12, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Fabio Pichierri
Jun 26, 2013·Nature Reviews. Gastroenterology & Hepatology·Gary M Mawe, Jill M Hoffman
Sep 3, 2013·Journal of the American Chemical Society·Frank BiedermannWerner M Nau
Feb 17, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Karina ScholtbachDenis Fuentealba
Mar 19, 2016·Organic & Biomolecular Chemistry·Hang CongGang Wei
Sep 28, 2016·Journal of the American Chemical Society·Alexandra I LazarWerner M Nau
Nov 30, 2016·Chemistry, an Asian Journal·Nilotpal BarooahJyotirmayee Mohanty
Mar 30, 2017·Frontiers in Cellular Neuroscience·Junhua Lv, Feng Liu
May 5, 2017·Organic & Biomolecular Chemistry·Hang YinRuibing Wang
Jul 12, 2017·Annals of the New York Academy of Sciences·Kit Ieng KuokRuibing Wang
Sep 1, 2017·Journal of Psychopharmacology·R L Carhart-Harris, D J Nutt
Oct 2, 2019·Frontiers in Chemistry·Debapratim DasWerner M Nau
Mar 25, 2020·Biomedical Optics Express·Guillermo A Hernández-MendozaFrancisco F De-Miguel

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Citations

Jun 3, 2021·Nanomaterials·Alina AktanovaVladimir Kozlov

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Methods Mentioned

BETA
NMR
Fluorescence Spectroscopy
Fluorescence
fluorescence titration
fluorescence binding

Software Mentioned

IBH
DAS
Origin pro
PatchDock

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