Supramolecular interactions between functional metal complexes and proteins

Dalton Transactions : an International Journal of Inorganic Chemistry
Catherine L DaviesAnne-K Duhme-Klair

Abstract

This perspective illustrates the principles and applications of molecular recognition directed binding of transition metal complexes to proteins. After a brief introduction into non-covalent interactions and the importance of complementarity, the focus of the first part is on biological systems that rely on non-covalent forces for metal complex binding, such as proteins involved in bacterial iron uptake and the oxygen-storage protein myoglobin. The second part of the perspective will illustrate how the replacement of native with non-native metal-centres can give rise to artificial metalloenzymes with novel catalytic properties. Subsequently, examples of spectroscopic probes that exploit the characteristic photophysical properties of metal-complexes for the non-covalent labelling, visualisation and investigation of proteins will be described. Finally, the use of kinetically inert metal complexes as scaffolds in drug design will be discussed and it will be highlighted how the binding of metal ions or organometallic fragments to existing drugs or drug candidates can improve their activity or even alter their mode of action.

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Citations

Apr 20, 2013·Journal of Inorganic Biochemistry·Valentin V NovikovYan Z Voloshin
Jun 5, 2013·Accounts of Chemical Research·Lei GongEric Meggers
Mar 31, 2011·Journal of the American Chemical Society·Li FengEric Meggers
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Aug 8, 2015·Inorganic Chemistry·Rajathees RajaratnamEric Meggers
Dec 4, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Masahisa OsawaMasataka Yashima
Feb 20, 2014·ChemistryOpen·Kathrin WählerEric Meggers
Jan 1, 2014·Chembiochem : a European Journal of Chemical Biology·Hao YangJared C Lewis
Nov 8, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Pattira SuktanarakPannee Leeladee
Jan 16, 2019·Metallomics : Integrated Biometal Science·Ali YounesClaude Vidaud
Oct 25, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Carmen E CastilloShalini Singh
Sep 14, 2012·Chemical Society Reviews·Zeyuan DongJunqiu Liu
Jun 27, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Sebastian BlanckEric Meggers
Mar 19, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Liang-An ChenEric Meggers
Jun 15, 2013·Angewandte Chemie·Dik-Lung MaChung-Hang Leung
Jul 18, 2017·Chemical Reviews·Fabian SchwizerThomas R Ward
Oct 8, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Sanya Pachisia, Rajeev Gupta

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