Supramolecular nanoparticles based on β-CD modified hyaluronic acid for DNA encapsulation and controlled release

Chemical Communications : Chem Comm
Yang YangYu Liu

Abstract

Supramolecular nanoparticles composed of doubly positively charged adamantane (ADA2+) and β-CD modified hyaluronic acid (HACD) were constructed. When the ester group in ADA2+ was hydrolyzed to a carboxyl group, the quaternary ammonium chain with a positive charge in ADA2+ converted to a "zwitterionic" structure, and the controlled binding and release of pDNA was realized.

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Citations

Jan 12, 2019·Chemical Communications : Chem Comm·Yu-Hui ZhangYu Liu

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Methods Mentioned

BETA
transfection
atomic
transmission
dynamic light scattering
AFM
electrophoresis

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